CHN1 and ANKK1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CHN1	ANKK1
Description		chimerin 1	ankyrin repeat and kinase domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm Cell Projection
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding Ephrin Receptor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Signal Transduction Nervous System Development Motor Neuron Axon Guidance Ephrin Receptor Signaling Pathway Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction	Regulation Of Cell Cycle Process Cellular Response To Retinoic Acid
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle
Drugs			Fostamatinib
Diseases		Duane retraction syndrome
GWAS		Post bronchodilator FEV1 ( 26634245)	Alcohol consumption (drinks per week) ( 30643258) Alcoholic chronic pancreatitis ( 28754779) Body mass index ( 26426971) Experiencing mood swings ( 29500382)
Interacting Genes		16 interacting genes: ACVR1 ADORA2A ANKK1 BMPR1B CDK5 CDK5R1 ERBB2 GTF3C1 HEMK1 HTR6 MAPK1 MAPK8IP2 NCK2 RAC1 RPS3A TGFBR1	4 interacting genes: C12orf57 CATSPERT CHN1 CHN2
Entrez ID		1123	255239
HPRD ID		00319	10580
Ensembl ID		ENSG00000128656	ENSG00000170209
Uniprot IDs		P15882	Q8NFD2
PDB IDs		2OSA 3CXL
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Kinase Activity Positive Regulation Of Signaling Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Cell Projection Organization Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Signal Transduction Schwann Cell Development Regulation Of Apoptotic Signaling Pathway Protein Serine/threonine Kinase Activity Neuron Projection Guidance Axon Guidance Positive Regulation Of Protein Targeting To Membrane Motor Neuron Axon Guidance Dendrite Protein Kinase 5 Complex Cerebral Cortex Cell Migration Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Targeting To Membrane Positive Regulation Of Apoptotic Process Cell Migration Response To Growth Factor Positive Regulation Of Programmed Cell Death Positive Regulation Of Establishment Of Protein Localization Chemical Synaptic Transmission Plasma Membrane Bounded Cell Projection Organization ErbB-3 Class Receptor Binding Telencephalon Cell Migration Growth Factor Binding Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Forebrain Cell Migration Trans-synaptic Signaling SMAD Binding Synaptic Signaling Dendrite Morphogenesis Neuronal Cell Body Neuron Differentiation Regulation Of Protein Modification Process Positive Regulation Of Supramolecular Fiber Organization Activin Receptor Complex Activin Receptor Activity, Type I Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway	Regulation Of Small GTPase Mediated Signal Transduction GTPase Activator Activity Corpus Callosum Morphogenesis Psychomotor Behavior Third Ventricle Development CatSper Complex Motor Neuron Axon Guidance Ephrin Receptor Binding Developmental Process Acrosome Assembly Central Nervous System Projection Neuron Axonogenesis Central Nervous System Neuron Axonogenesis Regulation Of Skeletal Muscle Contraction Motor Behavior Camera-type Eye Morphogenesis Sperm Principal Piece Sperm Capacitation
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