CEP250 and PHF20

		CEP250	PHF20
Description		centrosomal protein 250	PHD finger protein 20
Image
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Cilium Spindle Pole Centrosome Protein-containing Complex Ciliary Basal Body Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome	Histone Acetyltransferase Complex Nucleus Nucleoplasm Cytosol Nuclear Membrane NSL Complex MLL1 Complex
	Molecular Function	Protein Binding Protein Domain Specific Binding	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Intracellular Protein Localization Centriole-centriole Cohesion Cell Projection Organization Regulation Of Centriole-centriole Cohesion Protein Localization To Organelle Detection Of Light Stimulus Involved In Visual Perception Cilium Assembly Protein Localization To Centrosome Positive Regulation Of Protein Localization To Centrosome Non-motile Cilium Assembly	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	HATs acetylate histones Regulation of TP53 Degradation Regulation of TP53 Activity through Association with Co-factors Stabilization of p53 Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Brain morphology (MOSTest) ( 32665545) Height ( 18391951 25429064 34270706) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278) Ulcerative colitis ( 23128233) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	General cognitive ability ( 29844566) Height ( 25282103 28552196) Hip circumference adjusted for BMI ( 34021172) Mean platelet volume ( 32888494) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		15 interacting genes: APP ATF7IP FAM83D FRMD5 ITCH KAT2B KCNG3 MYL9 NEK2 PDIA6 PHF20 PLEKHA5 TTI1 USP7 YWHAG	4 interacting genes: CEP250 H3C1 H4C1 LIG1
Entrez ID		11190	51230
HPRD ID		09877	08514
Ensembl ID		ENSG00000126001	ENSG00000025293
Uniprot IDs		A0A9L9PXD2 Q9BV73	Q9BVI0
PDB IDs		6OQA	2LDM 3P8D 3Q1J 3QII 3SD4 5TAB 5TBN
Enriched GO Terms of Interacting Partners?		Regulation Of TOR Signaling Negative Regulation Of Gene Expression Epigenetic Regulation Of Gene Expression Regulation Of Protein Catabolic Process Positive Regulation Of Glycolytic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Histone Acetyltransferase Complex Protein-containing Complex Chromatin Organization Positive Regulation Of ATP Metabolic Process Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Cytosol Negative Regulation Of Centriole-centriole Cohesion Regulation Of Gluconeogenesis Protein Stabilization Positive Regulation Of Catabolic Process Regulation Of Chromosome Organization Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of ATP Metabolic Process Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Carbohydrate Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Small Molecule Metabolic Process Lipoprotein Particle Positive Regulation Of Cell Cycle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Cell Cycle Regulation Of Centriole-centriole Cohesion Negative Regulation Of TORC1 Signaling TOR Signaling Protein Kinase C Inhibitor Activity Cellular Response To Nutrient Levels TORC1 Signaling Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of RRNA Processing	Okazaki Fragment Processing Involved In Mitotic DNA Replication Nucleosome Telomere Organization Nucleosome Assembly Protein-containing Complex Nucleosome Organization Structural Constituent Of Chromatin DNA Ligase (ATP) Activity Lagging Strand Elongation DNA Replication, Okazaki Fragment Processing DNA Ligase Activity Protein-DNA Complex Assembly Regulation Of Centriole-centriole Cohesion Positive Regulation Of Protein Localization To Centrosome Protein Heterodimerization Activity Chromosome Organization DNA Strand Elongation Involved In DNA Replication Base-excision Repair, Gap-filling Centriole-centriole Cohesion Regulation Of Protein Localization To Centrosome Spindle Pole Centrosome V(D)J Recombination DNA Strand Elongation CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Detection Of Light Stimulus Involved In Visual Perception Extracellular Exosome Protein Localization To Centrosome Mismatch Repair DNA Binding Protein Localization To Organelle Base-excision Repair Chromatin Remodeling Regulation Of Megakaryocyte Differentiation Chromosome Protein Localization To Chromosome, Centromeric Region Cellular Component Assembly Somatic Cell DNA Recombination Organelle Organization Protein Localization To Cytoskeleton Protein Localization To Chromatin Non-motile Cilium Assembly Chromatin Organization Photoreceptor Inner Segment Detection Of Light Stimulus Photoreceptor Outer Segment
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?