HIBADH and SEC22B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HIBADH	SEC22B
Description		3-hydroxyisobutyrate dehydrogenase	SEC22 homolog B, vesicle trafficking protein
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome
	Molecular Function	Protein Binding 3-hydroxyisobutyrate Dehydrogenase Activity Oxidoreductase Activity NADP Binding NAD Binding	SNAP Receptor Activity Protein Binding
	Biological Process	L-valine Catabolic Process Branched-chain Amino Acid Catabolic Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process Membrane Fusion Negative Regulation Of Autophagosome Assembly
Pathways		Branched-chain amino acid catabolism	ER-Phagosome pathway COPII-mediated vesicle transport Cargo concentration in the ER COPI-dependent Golgi-to-ER retrograde traffic
Drugs		NADH
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Asthma ( 31959851) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Kidney stones ( 31729369) Lead levels in blood ( 25820613) Pulse pressure ( 27841878) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Systolic blood pressure ( 27841878)	Iris color (L* coordinate) ( 30895295)
Interacting Genes		39 interacting genes: ADAM33 AGTRAP AIG1 AMELY AQP3 ASGR1 BRCA1 C2CD2L CDS2 CLEC2A CMTM7 CNIH2 COMT CTSA EFNA5 ERMP1 GOSR2 MAL NDUFB11 PAEP PLN PRAF2 PTCH1 RTP2 SCARB2 SEC22B SFT2D2 SNORC TFRC TM6SF2 TMEM14B TMEM222 TMEM60 TMEM86B TRIM63 UBIAD1 VAMP2 VAMP5 ZFPL1	58 interacting genes: ABHD16A AIG1 AQP6 B3GAT3 CD160 CD79A CERS6 CLDN7 CLRN1 CPLX4 CREB3 CREB3L1 DPM3 EBP ELOVL4 ERGIC3 FAM174A FAM209A FCER1G FNDC9 GJA8 GJB5 GJB6 GORAB GPR152 GPX8 HIBADH HSD17B13 IFNGR2 JAGN1 KIR2DL3 LHFPL1 LHFPL5 LMNA MFF MGST2 MGST3 MMGT1 MRPS18B MUC1 NDUFAF2 REEP4 RELL2 RHBDD1 SERINC2 SLC10A6 SLC35H1 STX1A STX2 STX4 STX5 TLCD4 TM4SF19 TMEM132D TMEM139 TMEM167B TMEM229B TMEM86B
Entrez ID		11112	9554
HPRD ID		12238	04939
Ensembl ID		ENSG00000106049	ENSG00000265808
Uniprot IDs		A0A024RA75 P31937	O75396
PDB IDs		2GF2 2I9P	2NUP 2NUT 3EGD 3EGX 8HR0
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Establishment Of Protein Localization Endoplasmic Reticulum Endomembrane System Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane SNAP Receptor Activity Establishment Of Protein Localization To Membrane Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization To Plasma Membrane ER To Golgi Transport Vesicle Membrane Intracellular Protein Localization Clathrin-coated Endocytic Vesicle Membrane	Membrane Endoplasmic Reticulum Membrane SNARE Complex SNARE Binding SNAP Receptor Activity Exocytosis Endoplasmic Reticulum Protein Binding Positive Regulation Of Regulated Secretory Pathway Connexin Complex Gap Junction Channel Activity Secretion By Cell Vesicle Docking Glutathione Peroxidase Activity Gap Junction Leukotriene-C4 Synthase Activity Cornified Envelope Assembly Organelle Localization By Membrane Tethering Gap Junction-mediated Intercellular Transport Positive Regulation Of Exocytosis Membrane Docking Secretion Vesicle Fusion Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Organelle Membrane Fusion Intercellular Transport SNARE Complex Assembly Lipid Metabolic Process Regulation Of Regulated Secretory Pathway Membrane Assembly Organelle Fusion Regulation Of Secretion Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
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