HIBADH

Description		3-hydroxyisobutyrate dehydrogenase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding 3-hydroxyisobutyrate Dehydrogenase Activity Oxidoreductase Activity NADP Binding NAD Binding
	Biological Process	L-valine Catabolic Process Branched-chain Amino Acid Catabolic Process
Pathways		Branched-chain amino acid catabolism
Drugs		NADH
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Asthma ( 31959851) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Kidney stones ( 31729369) Lead levels in blood ( 25820613) Pulse pressure ( 27841878) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Systolic blood pressure ( 27841878)
Novel Interacting Genes		39 novel interacting genes: ADAM33 AGTRAP AIG1 AMELY AQP3 ASGR1 BRCA1 C2CD2L CDS2 CLEC2A CMTM7 CNIH2 COMT CTSA EFNA5 ERMP1 GOSR2 MAL NDUFB11 PAEP PLN PRAF2 PTCH1 RTP2 SCARB2 SEC22B SFT2D2 SNORC TFRC TM6SF2 TMEM14B TMEM222 TMEM60 TMEM86B TRIM63 UBIAD1 VAMP2 VAMP5 ZFPL1
Interacting Genes		39 interacting genes: ADAM33 AGTRAP AIG1 AMELY AQP3 ASGR1 BRCA1 C2CD2L CDS2 CLEC2A CMTM7 CNIH2 COMT CTSA EFNA5 ERMP1 GOSR2 MAL NDUFB11 PAEP PLN PRAF2 PTCH1 RTP2 SCARB2 SEC22B SFT2D2 SNORC TFRC TM6SF2 TMEM14B TMEM222 TMEM60 TMEM86B TRIM63 UBIAD1 VAMP2 VAMP5 ZFPL1
Entrez ID		11112
HPRD ID		12238
Ensembl ID		ENSG00000106049
Uniprot IDs		A0A024RA75 P31937
PDB IDs		2GF2 2I9P
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Establishment Of Protein Localization Endoplasmic Reticulum Endomembrane System Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane SNAP Receptor Activity Establishment Of Protein Localization To Membrane Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization To Plasma Membrane ER To Golgi Transport Vesicle Membrane Intracellular Protein Localization Clathrin-coated Endocytic Vesicle Membrane
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