RPP14 and GEMIN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RPP14	GEMIN2
Description		ribonuclease P/MRP subunit p14	gem nuclear organelle associated protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Ribonuclease P Complex Multimeric Ribonuclease P Complex Endoribonuclease Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Cytosol Nuclear Body SMN Complex SMN-Sm Protein Complex Gemini Of Cajal Bodies
	Molecular Function	RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding	Protein Binding
	Biological Process	TRNA 5'-leader Removal TRNA Processing	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly MRNA Processing RNA Splicing Protein-containing Complex Assembly
Pathways		tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol	snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs
Diseases
GWAS		Height ( 28552196) Hemoglobin levels ( 32327693) Mitochondrial heteroplasmy measurement ( 33731350) Platelet distribution width ( 32888494) Refractive error ( 32231278) Rheumatoid arthritis (ACPA-positive) ( 24532676) Total cholesterol levels ( 30275531)	Vitamin D levels ( 28757204)
Interacting Genes		22 interacting genes: A2M ACTN2 ATP5F1B CAPZB DOCK7 EXOSC8 GEMIN2 IGSF21 KMT2B LIMD1 MSH2 NOVA1 PKM POP4 POP5 PSME1 RPP25 RPP30 RPP38 RPP40 WIZ ZNF277	34 interacting genes: AKAP6 BEND7 DDX20 DHX9 FBXO7 GEMIN5 HOXD10 IKBKG INCA1 KPNA6 MEOX1 MTNR1A NUFIP1 PAX6 PSMB1 RN7SL1 RNU1-1 RNU2-1 RPP14 SMN1 SMN2 SNRNP70 SNRPD1 SNRPD2 SNRPD3 SNRPN SPG21 SRSF1 SRSF2 SRSF3 SRSF4 STXBP2 STXBP3 U2AF2
Entrez ID		11102	8487
HPRD ID		18001	03999
Ensembl ID		ENSG00000163684	ENSG00000092208
Uniprot IDs		O95059	A0A8J9FJK1 A0A8J9FN78 O14893
PDB IDs		6AHR 6AHU	2LEH 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU
Enriched GO Terms of Interacting Partners?		Ribonuclease MRP Complex Ribonuclease P RNA Binding Multimeric Ribonuclease P Complex Ribonuclease P Activity TRNA 5'-leader Removal TRNA 5'-end Processing Nucleolar Ribonuclease P Complex TRNA Metabolic Process RRNA Processing Ribonuclease P Complex TRNA Processing RRNA Metabolic Process RNA Processing Nucleolus Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Nucleoplasm RNA Binding Nucleic Acid Metabolic Process Nucleus Actin Filament Uncapping Ribonuclease MRP Activity	RNA Splicing MRNA Processing SMN-Sm Protein Complex Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions RNA Processing MRNA Metabolic Process Spliceosomal SnRNP Assembly RNA Metabolic Process MRNA Splicing, Via Spliceosome U1 SnRNP Spliceosomal Complex Assembly RNA Binding U2 SnRNP SMN Complex U4 SnRNP Nucleoplasm Nucleic Acid Metabolic Process Gemini Of Cajal Bodies Regulation Of MRNA Processing Small Nuclear Ribonucleoprotein Complex Protein-containing Complex Assembly Spliceosomal Complex U5 SnRNP Commitment Complex Regulation Of MRNA Splicing, Via Spliceosome PICln-Sm Protein Complex Protein-containing Complex Organization Nucleobase-containing Compound Metabolic Process 7-methylguanosine Cap Hypermethylation MRNA Binding Catalytic Step 2 Spliceosome U4/U6 X U5 Tri-snRNP Complex Regulation Of RNA Splicing Methylosome Sequence-specific MRNA Binding Regulation Of MRNA Metabolic Process Nucleus U2-type Prespliceosome Nuclear Body DNA-templated Transcription Termination Precatalytic Spliceosome Ribonucleoprotein Complex Regulation Of Alternative MRNA Splicing, Via Spliceosome Tertiary Granule Nucleic Acid Binding Cellular Response To Cytokine Stimulus U2-type Prespliceosome Assembly U12-type Spliceosomal Complex Cytoplasmic Ribonucleoprotein Granule
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