TRIOBP and DNAL4

		TRIOBP	DNAL4
Description		TRIO and F-actin binding protein	dynein axonemal light chain 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Chromosome Cytoplasm Centrosome Cytoskeleton Focal Adhesion Actin Cytoskeleton Midbody Stereocilium Base	Cytoplasm Cytoskeleton Microtubule Plasma Membrane Cilium Dynein Complex Cell Projection
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Myosin II Binding Actin Filament Binding	Microtubule Motor Activity Protein Binding Identical Protein Binding
	Biological Process	Sensory Perception Of Sound Actin Modification Barbed-end Actin Filament Capping Cell Division Auditory Receptor Cell Stereocilium Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Microtubule-based Process Microtubule-based Movement
Pathways			Retrograde neurotrophin signalling
Drugs
Diseases
GWAS		Adult hearing difficulty ( 31564434) Age-related hearing impairment ( 27764096 34108613) Age-related hearing impairment (low/mid frequency) ( 31645637) Basophil count ( 32888494) Brain morphology (MOSTest) ( 32665545) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673) Intraocular pressure ( 29617998 29785010 30054594 31959993) Lateral ventricular volume in normal aging ( 30258056) Optic cup area ( 28073927 25631615) Pulse pressure ( 30224653) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		12 interacting genes: DNAL4 DSCR9 FXR1 FXR2 GTF2H1 HECTD3 IKBKG LCOR PLK1 POLR1C TSC1 VIM	23 interacting genes: CACNA1I CHIC2 DDX17 DYNLL2 FHL5 GNA14 GPBP1 GTPBP1 HMGXB4 JOSD1 KRTAP10-3 KRTAP12-3 KRTAP9-8 NFATC2IP NOTCH2NLA NTAQ1 NUDT22 RHOT2 SCTR TOM1 TRIM54 TRIOBP UBA7
Entrez ID		11078	10126
HPRD ID		11028	13239
Ensembl ID		ENSG00000100106	ENSG00000100246
Uniprot IDs		Q9H2D6	O96015
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity Transcription By RNA Polymerase I Translation Regulator Activity Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of MRNA Stability Regulation Of RNA Stability Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Catabolic Process Memory T Cell Differentiation Regulation Of Neuronal Synaptic Plasticity
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