DDX52 and HLCS

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DDX52	HLCS
Description		DExD-box helicase 52	holocarboxylase synthetase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity ATP Binding Hydrolase Activity ATP Hydrolysis Activity	Nucleotide Binding Catalytic Activity Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Enzyme Binding Identical Protein Binding
	Biological Process	Maturation Of SSU-rRNA	Biotin Metabolic Process Post-translational Protein Modification Response To Biotin
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs			Biotin
Diseases			Holocarboxylase synthetase deficiency
GWAS		Ovarian cancer ( 23535730)	Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)
Interacting Genes		5 interacting genes: AP4M1 HLCS MTNR1A PMP22 UTP23	19 interacting genes: ACACB ANKRD29 BACH1 DDX52 IFNAR2 IFNGR2 IFT20 KRTAP5-9 LANCL2 MED19 NGB POT1 QKI SARS2 SNX27 SOD1 TGM3 TXNDC15 WIPF1
Entrez ID		11056	3141
HPRD ID		09911	08360
Ensembl ID		ENSG00000278053	ENSG00000159267
Uniprot IDs		B3KM65 Q9Y2R4	A0A8C8QSB1 P50747
PDB IDs		3DKP
Enriched GO Terms of Interacting Partners?		Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Biotin Metabolic Process Response To Biotin Melatonin Receptor Activity Compact Myelin Protein Localization To Basolateral Plasma Membrane AP-4 Adaptor Complex Biotin Binding Small Ribosomal Subunit RRNA Binding Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Bleb Assembly Golgi To Lysosome Transport Clathrin Adaptor Complex Nuclear Lamina Golgi To Endosome Transport Myelin Assembly Hormone Binding Endonucleolytic Cleavage Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
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