STIP1 and CBX4

Number of citations of the paper that reports this interaction (PubMedID 23938469)
66

Data Source:
BioGRID (two hybrid)

		STIP1	CBX4
Description		stress induced phosphoprotein 1	chromobox 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Protein-containing Complex Protein Folding Chaperone Complex Dynein Axonemal Particle	Nucleus Nucleoplasm Nuclear Body Nuclear Speck PcG Protein Complex PRC1 Complex
	Molecular Function	RNA Binding Protein Binding Hsp90 Protein Binding	Transcription Cis-regulatory Region Binding Chromatin Binding Transcription Corepressor Activity Single-stranded RNA Binding Protein Binding Transferase Activity SUMO Transferase Activity Enzyme Binding SUMO Binding Phosphoprotein Binding SUMO Ligase Activity
	Biological Process	Cellular Response To Interleukin-7	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Protein Sumoylation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RND1 GTPase cycle	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs		Copper
Diseases
GWAS		A body shape index ( 34021172) Attention deficit hyperactivity disorder ( 21784300) Crohn's disease ( 28067908) Fruit consumption ( 32066663) Monocyte count ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284)
Interacting Genes		36 interacting genes: ACD ACVR1 AIP APP CBX4 CDC37 CHD3 CLCN1 CLK1 EGFR ERBB2 FEZ2 FKBP5 HIPK2 HSP90AA1 HSPA14 HSPA1A HSPA4 HSPA8 LAMB2 LMO2 MAGED4 MAP3K8 OGT PIAS2 PIAS3 PIAS4 POT1 PRNP PTGES3 RASGRF1 SUMO2 SUMO4 UBE2I UBR5 YIF1A	28 interacting genes: ARID3C CBS CHD3 CREBBP CTBP1 CTBP2 FHL1 H3-3A H3-4 H3C1 H3C14 KMT2A LNX2 MBD1 MED9 MX1 RB1 RING1 RNF2 SATB1 SKIL SPOP STIP1 SUV39H1 TRIM21 UBE2I ZBED1 ZEB2
Entrez ID		10963	8535
HPRD ID		05454	04357
Ensembl ID		ENSG00000168439	ENSG00000141582
Uniprot IDs		P31948 V9HW72	A0A0S2Z5B2 O00257
PDB IDs		1ELR 1ELW 2LNI 2NC9 3ESK 3FWV 7KW7	2K28 3I8Z 5EPL
Enriched GO Terms of Interacting Partners?		SUMO Transferase Activity Protein Sumoylation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Protein Folding ATP-dependent Protein Folding Chaperone SUMO Ligase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription PML Body Chaperone-mediated Protein Complex Assembly Unfolded Protein Binding Telomere Maintenance Via Telomerase Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process RNA-templated DNA Biosynthetic Process Heat Shock Protein Binding Protein Refolding Negative Regulation Of RNA Metabolic Process Telomere Maintenance Via Telomere Lengthening Regulation Of DNA-templated Transcription Protein Folding Chaperone Complex Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Protein Localization Regulation Of Signal Transduction Regulation Of Telomere Maintenance Via Telomerase Protein-folding Chaperone Binding ATP Binding Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Folding Chaperone Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II Regulation Of Signaling	Chromatin Remodeling Nucleus Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II PML Body Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process RING-like Zinc Finger Domain Binding DNA Binding Chromosome Structural Constituent Of Chromatin Protein-DNA Complex Assembly Zinc Ion Binding Nucleosome Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Centromere Complex Assembly Nucleosome Transcription Coregulator Binding Identical Protein Binding Sex Chromatin Nucleosome Organization Positive Regulation Of RNA Metabolic Process Heterochromatin Formation Heterochromatin Transcription Coactivator Activity Unmethylated CpG Binding Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Chromatin
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