STIP1 and PTGES3

Number of citations of the paper that reports this interaction (PubMedID 26344197)
49

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		STIP1	PTGES3
Description		stress induced phosphoprotein 1	prostaglandin E synthase 3
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Protein-containing Complex Protein Folding Chaperone Complex Dynein Axonemal Particle	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Cytoplasm Cytosol Protein-containing Complex Protein Folding Chaperone Complex
	Molecular Function	RNA Binding Protein Binding Hsp90 Protein Binding	Telomerase Activity Protein Binding Isomerase Activity Prostaglandin-E Synthase Activity Unfolded Protein Binding Protein-folding Chaperone Binding Hsp90 Protein Binding DNA Polymerase Binding
	Biological Process	Cellular Response To Interleukin-7	Telomere Maintenance Prostaglandin Biosynthetic Process Protein Folding Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Telomere Maintenance Via Telomerase Signal Transduction Positive Regulation Of Telomere Maintenance Via Telomerase Prostanoid Biosynthetic Process Protein Stabilization Chaperone-mediated Protein Complex Assembly Telomerase Holoenzyme Complex Assembly
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RND1 GTPase cycle	Synthesis of Prostaglandins (PG) and Thromboxanes (TX) HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand HSF1 activation Attenuation phase Aryl hydrocarbon receptor signalling ESR-mediated signaling Estrogen-dependent gene expression Potential therapeutics for SARS
Drugs		Copper	Acetaminophen Grn163l Copper
Diseases
GWAS		A body shape index ( 34021172) Attention deficit hyperactivity disorder ( 21784300) Crohn's disease ( 28067908) Fruit consumption ( 32066663) Monocyte count ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Alanine aminotransferase levels ( 33547301) Asthma ( 31619474) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Mean platelet volume ( 22139419) Platelet count ( 22139419) Reticulocyte count ( 32888494)
Interacting Genes		36 interacting genes: ACD ACVR1 AIP APP CBX4 CDC37 CHD3 CLCN1 CLK1 EGFR ERBB2 FEZ2 FKBP5 HIPK2 HSP90AA1 HSPA14 HSPA1A HSPA4 HSPA8 LAMB2 LMO2 MAGED4 MAP3K8 OGT PIAS2 PIAS3 PIAS4 POT1 PRNP PTGES3 RASGRF1 SUMO2 SUMO4 UBE2I UBR5 YIF1A	30 interacting genes: AHR AHSA1 AIP ARNT CASP3 CASP7 CAV3 CD2AP CDC37 COPG1 COPG2 DNAJB1 DNMT3A EIF2AK2 ERBB3 ESR1 FES GZMB HSF1 HSP90AA1 HSPA1A HSPB1 MAPT NR3C1 NR3C2 SIM2 STIP1 SURF1 TERT THRA
Entrez ID		10963	10728
HPRD ID		05454	06138
Ensembl ID		ENSG00000168439	ENSG00000110958
Uniprot IDs		P31948 V9HW72	A0A087WYT3 B3KUY2 Q15185
PDB IDs		1ELR 1ELW 2LNI 2NC9 3ESK 3FWV 7KW7	1EJF 7KRJ 7L7I 7L7J
Enriched GO Terms of Interacting Partners?		SUMO Transferase Activity Protein Sumoylation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Protein Folding ATP-dependent Protein Folding Chaperone SUMO Ligase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription PML Body Chaperone-mediated Protein Complex Assembly Unfolded Protein Binding Telomere Maintenance Via Telomerase Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process RNA-templated DNA Biosynthetic Process Heat Shock Protein Binding Protein Refolding Negative Regulation Of RNA Metabolic Process Telomere Maintenance Via Telomere Lengthening Regulation Of DNA-templated Transcription Protein Folding Chaperone Complex Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Protein Localization Regulation Of Signal Transduction Regulation Of Telomere Maintenance Via Telomerase Protein-folding Chaperone Binding ATP Binding Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Folding Chaperone Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II Regulation Of Signaling	Hsp90 Protein Binding Nuclear Receptor Activity TBP-class Protein Binding Unfolded Protein Binding Response To Temperature Stimulus Response To Heat Regulation Of Gene Expression Cellular Response To Heat Regulation Of Macromolecule Biosynthetic Process Response To Lipid Protein Folding Chaperone Regulation Of Macromolecule Metabolic Process Aryl Hydrocarbon Receptor Complex Regulation Of Apoptotic Process Protein Folding Chaperone Complex Cytoplasm Positive Regulation Of Microtubule Polymerization Positive Regulation Of Protein Polymerization Response To Unfolded Protein Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Intracellular Signal Transduction Regulation Of Metabolic Process Cytosol Response To Stress Regulation Of Protein-containing Complex Assembly Estrogen Response Element Binding Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Lipid Protein-folding Chaperone Binding Negative Regulation Of Inclusion Body Assembly Protein Folding Negative Regulation Of Biosynthetic Process Animal Organ Development Regulation Of Cellular Response To Heat Intracellular Receptor Signaling Pathway Nuclear Aryl Hydrocarbon Receptor Complex Neurofibrillary Tangle Assembly Protein-containing Complex Regulation Of Neuron Apoptotic Process Regulation Of Microtubule Polymerization Regulation Of Inclusion Body Assembly Negative Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Response To Hormone Positive Regulation Of Metabolic Process Response To Hypoxia Sequence-specific DNA Binding Cellular Response To Oxygen-containing Compound DNA-binding Transcription Factor Activity
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