SEC61B and MORC3

		SEC61B	MORC3
Description		SEC61 translocon subunit beta	MORC family CW-type zinc finger 3
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GO Annotations	Cellular Component	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Quality Control Compartment	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Matrix PML Body
	Molecular Function	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Ribosome Binding Epidermal Growth Factor Binding	DNA Binding RNA Binding Protein Binding Zinc Ion Binding ATP Hydrolysis Activity Protein-macromolecule Adaptor Activity Metal Ion Binding Histone H3K4me3 Reader Activity
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Intracellular Protein Transport Protein Transport Retrograde Protein Transport, ER To Cytosol Post-translational Protein Targeting To Membrane, Translocation ERAD Pathway	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Chromatin Organization Protein Phosphorylation Post-embryonic Development Peptidyl-serine Phosphorylation Negative Regulation Of Interferon-beta Production Innate Immune Response Negative Regulation Of Fibroblast Proliferation Protein Stabilization Maintenance Of Protein Location In Nucleus Type I Interferon-mediated Signaling Pathway Antiviral Innate Immune Response Positive Regulation Of Cellular Senescence
Pathways		ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Adult body size ( 32376654) Asthma ( 31959851) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549)	Diastolic blood pressure ( 30224653) Height ( 31562340)
Interacting Genes		20 interacting genes: APOB ARL6 ATP13A2 AURKA BAG6 BMPR1A BUB1 CALM1 CDKN2A FBXW7 GET3 GET4 MCC MLH3 MORC3 MUTYH SEC63 SERP1 SPC25 TRAM1	31 interacting genes: ARK2N COPS5 DST DYNLL1 ERCC6 GALNT1 HOOK3 KALRN KIF3A KPNA2 KPNA4 MKLN1 PIAS1 PIAS3 PTK2 RANBP9 RETREG1 RNF123 RNF216 SEC61B SETD4 SNAPIN SPTBN4 SRI SUMO2 SUMO3 TBX1 UBC UBE2I ZBTB32 ZMYM5
Entrez ID		10952	23515
HPRD ID		06715	10316
Ensembl ID		ENSG00000106803	ENSG00000159256
Uniprot IDs		P60468	B4DHJ4 Q14149 Q4VBZ9
PDB IDs		6W6L 8B6L 8DNV 8DNW 8DNX 8DNY 8DNZ 8DO0 8DO1 8DO2 8DO3 8OJ0 8OJ8	4QQ4 5SVI 5SVX 5SVY 6O1E 6O5W
Enriched GO Terms of Interacting Partners?		Protein Targeting To Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane Protein Insertion Into Membrane Regulation Of Protein Stability Protein Targeting BAT3 Complex Protein Targeting To ER Establishment Of Protein Localization Maintenance Of Unfolded Protein Establishment Of Protein Localization To Endoplasmic Reticulum Localization Within Membrane Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Carrier Chaperone Intracellular Protein Localization Nucleoplasm Post-embryonic Development Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Protein Stabilization Cotranslational Protein Targeting To Membrane Regulation Of Mitotic Cell Cycle Outer Kinetochore Cellular Response To Stress Response To Stress Synaptonemal Complex Assembly Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Nuclear Division Synaptonemal Complex Organization Negative Regulation Of Protein Catabolic Process Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Signaling Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Negative Regulation Of Proteolysis Mismatch Repair Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Intracellular Protein Transmembrane Transport Negative Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Cell Cycle Phase Transition Negative Regulation Of Epithelial Cell Proliferation Mature Chylomicron Lipid Homeostasis Cellular Localization	Protein Sumoylation SUMO Transferase Activity Protein Modification By Small Protein Conjugation Presynaptic Cytosol Postsynaptic Cytosol Post-translational Protein Modification PML Body Protein Modification Process Protein Tag Activity Axon Cytoplasm Protein Metabolic Process Cytoskeleton-dependent Intracellular Transport Establishment Of Localization In Cell Nucleoplasm Macromolecule Metabolic Process NLS-dependent Protein Nuclear Import Complex Intracellular Transport Microtubule Anchoring At Centrosome Cellular Localization Axonal Transport Negative Regulation Of Heart Rate SUMO Ligase Activity Positive Regulation Of Protein Sumoylation Microtubule Anchoring At Microtubule Organizing Center Transport Along Microtubule Cell Cortex Axo-dendritic Transport Nucleus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Cytosol Microtubule-based Transport Nuclear Import Signal Receptor Activity Retrograde Axonal Transport Negative Regulation Of Heart Contraction Cytoplasm Enzyme Binding Nuclear Localization Sequence Binding Negative Regulation Of Blood Circulation Regulation Of Protein Sumoylation NLS-bearing Protein Import Into Nucleus Microtubule Anchoring Regulation Of Protein Modification Process Establishment Of Vesicle Localization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Protein Ligase Binding Spectrin Binding Proteolysis Involved In Protein Catabolic Process Establishment Of Organelle Localization Vesicle Localization
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