SEC61B and SEC63

Number of citations of the paper that reports this interaction (PubMedID 10799540)
0

Data Source:
HPRD (in vitro)

		SEC61B	SEC63
Description		SEC61 translocon subunit beta	SEC63 protein translocation regulator
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Quality Control Compartment	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sec62/Sec63 Complex
	Molecular Function	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Ribosome Binding Epidermal Growth Factor Binding	RNA Binding Protein Binding Protein Transmembrane Transporter Activity Signaling Receptor Activity
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Intracellular Protein Transport Protein Transport Retrograde Protein Transport, ER To Cytosol Post-translational Protein Targeting To Membrane, Translocation ERAD Pathway	Liver Development Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Transport Post-translational Protein Targeting To Membrane, Translocation Nitrogen Cycle Metabolic Process
Pathways		ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases			Polycystic liver disease
GWAS		Adult body size ( 32376654) Asthma ( 31959851) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549)	Graft survival time in renal transplantation (donor effect) x APOL1 genotype interaction ( 32080893)
Interacting Genes		20 interacting genes: APOB ARL6 ATP13A2 AURKA BAG6 BMPR1A BUB1 CALM1 CDKN2A FBXW7 GET3 GET4 MCC MLH3 MORC3 MUTYH SEC63 SERP1 SPC25 TRAM1	5 interacting genes: HSPA5 MEOX2 RNF10 SEC61B SEC62
Entrez ID		10952	11231
HPRD ID		06715	09783
Ensembl ID		ENSG00000106803	ENSG00000025796
Uniprot IDs		P60468	A0A0S2Z5M1 Q9UGP8
PDB IDs		6W6L 8B6L 8DNV 8DNW 8DNX 8DNY 8DNZ 8DO0 8DO1 8DO2 8DO3 8OJ0 8OJ8
Enriched GO Terms of Interacting Partners?		Protein Targeting To Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane Protein Insertion Into Membrane Regulation Of Protein Stability Protein Targeting BAT3 Complex Protein Targeting To ER Establishment Of Protein Localization Maintenance Of Unfolded Protein Establishment Of Protein Localization To Endoplasmic Reticulum Localization Within Membrane Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Carrier Chaperone Intracellular Protein Localization Nucleoplasm Post-embryonic Development Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Protein Stabilization Cotranslational Protein Targeting To Membrane Regulation Of Mitotic Cell Cycle Outer Kinetochore Cellular Response To Stress Response To Stress Synaptonemal Complex Assembly Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Nuclear Division Synaptonemal Complex Organization Negative Regulation Of Protein Catabolic Process Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Signaling Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Negative Regulation Of Proteolysis Mismatch Repair Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Intracellular Protein Transmembrane Transport Negative Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Cell Cycle Phase Transition Negative Regulation Of Epithelial Cell Proliferation Mature Chylomicron Lipid Homeostasis Cellular Localization	Post-translational Protein Targeting To Membrane, Translocation Intracellular Protein Transmembrane Transport Protein Transmembrane Transport ERAD Pathway Proteasomal Protein Catabolic Process Ribosome Binding Regulation Of Protein Folding In Endoplasmic Reticulum Intracellular Protein Transport Endoplasmic Reticulum Sec Complex Protein Catabolic Process Cerebellum Structural Organization Proteolysis Involved In Protein Catabolic Process Regulation Of ATF6-mediated Unfolded Protein Response Epidermal Growth Factor Binding Regulation Of Protein Folding Maintenance Of Protein Localization In Endoplasmic Reticulum Macromolecule Catabolic Process PERK-mediated Unfolded Protein Response Response To Endoplasmic Reticulum Stress ER Overload Response Endoplasmic Reticulum Membrane Endoplasmic Reticulum Chaperone Complex Negative Regulation Of PERK-mediated Unfolded Protein Response Protein Transport IRE1-mediated Unfolded Protein Response Transmembrane Transport Cerebellar Purkinje Cell Layer Development Protein Folding In Endoplasmic Reticulum Positive Regulation Of Transcription By RNA Polymerase II Intracellular Transport Proteolysis Negative Regulation Of IRE1-mediated Unfolded Protein Response Somite Specification Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Sec61 Translocon Complex SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Establishment Of Protein Localization Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Misfolded Protein Binding Segment Specification Somite Development Cotranslational Protein Targeting To Membrane Negative Regulation Of Glial Cell Proliferation Retrograde Protein Transport, ER To Cytosol Anatomical Structure Arrangement
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