MORF4L1 and PHF12

Number of citations of the paper that reports this interaction (PubMedID 12391155)
49

Data Source:
HPRD (two hybrid)

		MORF4L1	PHF12
Description		mortality factor 4 like 1	PHD finger protein 12
Image
GO Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Nuclear Speck NuA4 Histone Acetyltransferase Complex Sin3-type Complex	Nucleus Nucleoplasm Transcription Repressor Complex Sin3-type Complex
	Molecular Function	Chromatin Binding Protein Binding	Transcription Corepressor Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Phosphatidylinositol Binding Metal Ion Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination Chromatin Organization Regulation Of DNA-templated Transcription DNA Damage Response Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Fibroblast Proliferation Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription
Pathways		HATs acetylate histones
Drugs
Diseases
GWAS		Coronary artery disease ( 32469254 33020668) Coronary heart disease ( 21378988) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730 31577861) Lung cancer in ever smokers ( 28604730) Myocardial infarction ( 33532862) Pulse pressure ( 27841878 30578418) Refractive error ( 32231278) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		83 interacting genes: APP ARID3A ARRDC3 BEND7 BEX5 BTG3 CALM1 CAMK2B CEBPA CEP57L1 CWC27 DMAP1 DRAP1 DSCR9 DYSF EP300 FAM13C FAM9B FBXO16 FHL3 FXR2 GMCL1 GOLGA2 GOLGA6A GSC2 H3-4 H3C1 HINFP HMBOX1 IKZF1 KPNA2 L3MBTL3 LHX2 LMNA LZTS2 MEOX1 MEOX2 MRFAP1 MRFAP1L1 MRGBP MRPL12 MSL1 NAB2 NAV2 NECAB1 NKD1 NMI PBXIP1 PCM1 PHF12 PIBF1 PICK1 PLEKHA3 PSMC1 RACGAP1 RB1 RCBTB2 REL SH3GLB2 SYN3 TEPSIN TEX11 TFCP2 THAP1 TLE5 TNIP1 TNNT1 TNNT2 TRIM41 TTC3 TULP3 UBP1 USO1 VPS26A ZBTB10 ZBTB26 ZBTB43 ZBTB8B ZBTB9 ZC3H7A ZNF276 ZNF438 ZNF449	8 interacting genes: ATP6V0D2 BRCA1 H3-4 HDAC1 MORF4L1 NUFIP2 SHANK3 SIN3A
Entrez ID		10933	57649
HPRD ID		09532	15123
Ensembl ID		ENSG00000185787	ENSG00000109118
Uniprot IDs		Q9UBU8	Q96QT6
PDB IDs		2AQL 2EFI 2F5J 2F5K 2LKM 2N1D 6AGO 6INE 7S4A 8BPA 8C60	2L9S 2LKM 8BPA 8BPB 8BPC 8C60
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Nucleus Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Spermatogonial Cell Division Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Rb-E2F Complex Somite Specification Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Transcription Coregulator Activity Negative Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Transcription Corepressor Activity Troponin Complex Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Importin-alpha Family Protein Binding Regulation Of Protein Localization To Nucleus Positive Regulation Of Metabolic Process Regulation Of Skeletal Muscle Adaptation DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific	Sin3-type Complex Chromatin Organization Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Stem Cell Population Maintenance Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Chromatin Remodeling Regulation Of Intracellular Estrogen Receptor Signaling Pathway Histone Deacetylase Complex Forebrain Neuron Differentiation Condensed Nuclear Chromosome Epigenetic Regulation Of Gene Expression Positive Regulation Of Stem Cell Population Maintenance Heterochromatin P53 Binding Neuron Differentiation Transcription Repressor Complex Cellular Response To Tert-butyl Hydroperoxide Response To Methylglyoxal Regulation Of Stem Cell Population Maintenance Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Krueppel-associated Box Domain Binding Guanylate Kinase-associated Protein Clustering Plasma Membrane Proton-transporting V-type ATPase Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Chromatin Binding Regulation Of Cell Cycle G2/M Phase Transition Protein Lysine Delactylase Activity Fungiform Papilla Formation Nucleosome Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation BRCA1-B Complex Recombinational Repair Positive Regulation Of DNA Repair Double-strand Break Repair Via Homologous Recombination Protein Decrotonylase Activity Histone Decrotonylase Activity Spermatogonial Cell Division Central Nervous System Neuron Differentiation Synaptic Receptor Adaptor Activity Negative Regulation Of Cytoskeleton Organization Cellular Response To Indole-3-methanol Positive Regulation Of Developmental Process Regulation Of Developmental Process Hair Follicle Placode Formation
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