PHF12 and ATP6V0D2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PHF12	ATP6V0D2
Description		PHD finger protein 12	ATPase H+ transporting V0 subunit d2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Repressor Complex Sin3-type Complex	Lysosomal Membrane Endosome Early Endosome Endosome Membrane Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Phagocytic Vesicle Membrane Proton-transporting V-type ATPase, V0 Domain Plasma Membrane Proton-transporting V-type ATPase Complex Extracellular Exosome
	Molecular Function	Transcription Corepressor Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Phosphatidylinositol Binding Metal Ion Binding	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription	Monoatomic Ion Transport Vacuolar Transport Vacuolar Acidification Regulation Of Macroautophagy Proton Transmembrane Transport
Pathways			ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs			Tiludronic acid
Diseases
GWAS			Adverse response to lamotrigine and phenytoin ( 22379998) Neutrophil count ( 32888494)
Interacting Genes		8 interacting genes: ATP6V0D2 BRCA1 H3-4 HDAC1 MORF4L1 NUFIP2 SHANK3 SIN3A	20 interacting genes: ADRM1 AGO3 ARID5A CENPP CRX IKZF3 INCA1 MEOX2 NDUFB8 NICN1 PAX6 PHF12 POMC RBM15B REL RIBC1 RPS3 RUSC1 SEPTIN2 ZNF474
Entrez ID		57649	245972
HPRD ID		15123	16522
Ensembl ID		ENSG00000109118	ENSG00000147614
Uniprot IDs		Q96QT6	Q8N8Y2
PDB IDs		2L9S 2LKM 8BPA 8BPB 8BPC 8C60
Enriched GO Terms of Interacting Partners?		Sin3-type Complex Chromatin Organization Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Stem Cell Population Maintenance Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Chromatin Remodeling Regulation Of Intracellular Estrogen Receptor Signaling Pathway Histone Deacetylase Complex Forebrain Neuron Differentiation Condensed Nuclear Chromosome Epigenetic Regulation Of Gene Expression Positive Regulation Of Stem Cell Population Maintenance Heterochromatin P53 Binding Neuron Differentiation Transcription Repressor Complex Cellular Response To Tert-butyl Hydroperoxide Response To Methylglyoxal Regulation Of Stem Cell Population Maintenance Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Krueppel-associated Box Domain Binding Guanylate Kinase-associated Protein Clustering Plasma Membrane Proton-transporting V-type ATPase Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Chromatin Binding Regulation Of Cell Cycle G2/M Phase Transition Protein Lysine Delactylase Activity Fungiform Papilla Formation Nucleosome Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation BRCA1-B Complex Recombinational Repair Positive Regulation Of DNA Repair Double-strand Break Repair Via Homologous Recombination Protein Decrotonylase Activity Histone Decrotonylase Activity Spermatogonial Cell Division Central Nervous System Neuron Differentiation Synaptic Receptor Adaptor Activity Negative Regulation Of Cytoskeleton Organization Cellular Response To Indole-3-methanol Positive Regulation Of Developmental Process Regulation Of Developmental Process Hair Follicle Placode Formation	NF-kappaB Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleus Nucleoplasm Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II
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