PGRMC1 and CENPU

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		PGRMC1	CENPU
Description		progesterone receptor membrane component 1	centromere protein U
Image
GO Annotations	Cellular Component	Extracellular Region Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Plasma Membrane Endomembrane System Membrane Smooth Endoplasmic Reticulum Membrane Specific Granule Membrane Neuron Projection Neuronal Cell Body Cell Body Synapse	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Centriolar Satellite
	Molecular Function	Amyloid-beta Binding Steroid Binding Protein Binding Lipid Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding	Protein Binding
	Biological Process	Heme Biosynthetic Process Axon Guidance Memory Associative Learning Modification Of Synaptic Structure Positive Regulation Of Lipoprotein Transport Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Synapse Organization	Chromosome Segregation Chordate Embryonic Development
Pathways		Neutrophil degranulation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Dextromethorphan Nortriptyline Sertraline
Diseases
GWAS		Hodgkin's lymphoma ( 34216518)
Interacting Genes		21 interacting genes: BIK CAMLG CCDC134 CENPU CIAO1 CREB3L1 DEFB124 EVI2B GET3 GLP1R GOLM1 KASH5 KCNE5 LINC00632 MTNR1A MX1 PAM16 SCAP SGTB TMEM213 ZNF71	20 interacting genes: CENPQ E2F6 EIF4G1 GIT1 LAMC1 MLF1 NDUFS2 NUP62 OGT PGRMC1 PLK1 PLK2 PLK3 PLXNB2 ROBO2 SPTBN4 TFIP11 TUBB2B UPF2 XRCC6
Entrez ID		10857	79682
HPRD ID		02338	14722
Ensembl ID		ENSG00000101856	ENSG00000151725
Uniprot IDs		O00264 Q6IB11	Q71F23
PDB IDs		4X8Y	7PB8 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH 8K4D
Enriched GO Terms of Interacting Partners?		GET Complex	Regulation Of Cellular Component Organization Spindle Pole Regulation Of Cytokinesis Positive Regulation Of Protein Localization Regulation Of Cell Cycle Process Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Protein Localization To Cell Periphery Regulation Of Cell Division Regulation Of Protein Localization Centrosome Separation Regulation Of Protein-containing Complex Assembly Cytoskeleton Regulation Of Cell Cycle Negative Regulation Of Cellular Component Organization Negative Regulation Of Synapse Organization Cell Junction Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Spindle Organization Synapse Organization Organelle Organization Regulation Of Microtubule-based Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translation In Response To Stress Regulation Of Synapse Organization Regulation Of Centriole Replication Negative Regulation Of Macromolecule Biosynthetic Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Telomeric DNA Binding Negative Regulation Of Protein-containing Complex Assembly Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Spindle Organization Regulation Of Protein Catabolic Process Centrosome Cell Cycle Phase Transition Kinetochore Regulation Of Synapse Assembly Negative Regulation Of Catabolic Process Positive Regulation Of Translation Regulation Of Microtubule Cytoskeleton Organization Mitotic Spindle Pole Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chaperone-mediated Autophagy Regulation Of Protein Metabolic Process Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly
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