ADCY2 and AHRR

		ADCY2	AHRR
Description		adenylate cyclase 2	aryl hydrocarbon receptor repressor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Dendrite Membrane Raft	Chromatin Nucleus Nucleoplasm Cytoplasm Aryl Hydrocarbon Receptor Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Lyase Activity Phosphorus-oxygen Lyase Activity Manganese Ion Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Nuclear Receptor Activity Protein Binding Protein Dimerization Activity
	Biological Process	CAMP Biosynthetic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cyclic Nucleotide Biosynthetic Process Intracellular Signal Transduction Cellular Response To Forskolin	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Xenobiotic Metabolic Process Response To Xenobiotic Stimulus Intracellular Receptor Signaling Pathway
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling
Drugs		Colforsin Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Atorvastatin-induced myopathy ( 31220337) Bipolar disorder ( 31043756 34002096 24618891) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Bipolar I disorder ( 31043756) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Capecitabine sensitivity ( 22864933) Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Food addiction ( 27106561) LDL cholesterol levels in HIV infection ( 33109212) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Oropharynx cancer ( 27749845) Pars opercularis volume ( 31530798) Plasma factor VII activating protease levels ( 30070759) Posterior-cingulate cortex volume ( 31530798) Smoking status (heavy vs never) ( 26423011) Visceral fat ( 22589738)	Breast cancer ( 29059683) Cystic fibrosis severity ( 21602797) Estimated glomerular filtration rate ( 31015462) Fat distribution (HIV) ( 21897333) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29617998) Systolic blood pressure ( 30224653)
Interacting Genes		14 interacting genes: ADCY1 ADCY5 AHRR CDH18 DRD4 F2RL1 GCDH GNAS GNG2 ISL1 NUF2 OBP2A RDH12 SLC9A3	3 interacting genes: ADCY2 ARNT SLC6A3
Entrez ID		108	57491
HPRD ID		00052	07356
Ensembl ID		ENSG00000078295	ENSG00000063438
Uniprot IDs		Q08462 Q71UM8	A0A7I2PK40 A9YTQ3
PDB IDs			5Y7Y
Enriched GO Terms of Interacting Partners?		G Protein-coupled Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Secretion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Regulation Of Protein Transport G Protein-coupled Receptor Signaling Pathway Response To Ketone Cellular Response To Lipid CAMP Biosynthetic Process Adenylate Cyclase Activity Response To Alcohol Regulation Of Hormone Secretion Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Cellular Response To Forskolin Regulation Of Secretion By Cell Response To Forskolin Regulation Of Secretion Cellular Response To Catecholamine Stimulus Phosphorus-oxygen Lyase Activity Cellular Response To Prostaglandin E Stimulus Response To Catecholamine G-protein Beta-subunit Binding CAMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Response To Lipid Heterotrimeric G-protein Complex Regulation Of Biological Quality Nervous System Process Cyclic Purine Nucleotide Metabolic Process Regulation Of Protein Localization System Process Purine-containing Compound Biosynthetic Process Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Glutaryl-CoA Dehydrogenase Activity Positive Regulation Of Interleukin-1 Beta Production Nucleoside Phosphate Biosynthetic Process Calcium- And Calmodulin-responsive Adenylate Cyclase Activity Negative Regulation Of Protein Secretion Proteinase-activated Receptor Activity Positive Regulation Of Interleukin-1 Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Eosinophil Degranulation	Membrane Raft Response To Alcohol Nuclear Aryl Hydrocarbon Receptor Complex Positive Regulation Of Hormone Biosynthetic Process Aryl Hydrocarbon Receptor Binding Aryl Hydrocarbon Receptor Complex Intestinal Epithelial Structure Maintenance Hyaloid Vascular Plexus Regression Norepinephrine Uptake Dopamine Uptake Involved In Synaptic Transmission Catecholamine Catabolic Process Amine Binding Heterocyclic Compound Binding Monoamine Transmembrane Transporter Activity Norepinephrine:sodium Symporter Activity Dopamine Binding Norepinephrine Transport Dopamine Biosynthetic Process Dopamine:sodium Symporter Activity Adenohypophysis Development Dopamine Catabolic Process Flotillin Complex CAMP Biosynthetic Process Adenylate Cyclase Activity Catecholamine Uptake Dopamine Uptake Adenylate Cyclase Binding Positive Regulation Of Protein Sumoylation Dopaminergic Synapse Prepulse Inhibition Anatomical Structure Regression Cellular Response To Forskolin Phosphorus-oxygen Lyase Activity CAMP Metabolic Process Response To Forskolin Cyclic Nucleotide Biosynthetic Process Regulation Of Hormone Biosynthetic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Glycolytic Process Regulation Of Protein Sumoylation Maintenance Of Gastrointestinal Epithelium Regulation Of Dopamine Metabolic Process Dopamine Transport Neurotransmitter Reuptake Catecholamine Biosynthetic Process Neurotransmitter Transmembrane Transporter Activity Embryonic Placenta Development Protein Phosphatase 2A Binding Monoamine Transport Neurotransmitter Uptake
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