ADCY2 and CDH18

		ADCY2	CDH18
Description		adenylate cyclase 2	cadherin 18
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Dendrite Membrane Raft	Plasma Membrane Adherens Junction Membrane Catenin Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Lyase Activity Phosphorus-oxygen Lyase Activity Manganese Ion Binding Metal Ion Binding	Calcium Ion Binding Beta-catenin Binding Cadherin Binding Metal Ion Binding
	Biological Process	CAMP Biosynthetic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cyclic Nucleotide Biosynthetic Process Intracellular Signal Transduction Cellular Response To Forskolin	Cell Morphogenesis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Adherens Junction Organization Cell-cell Adhesion Mediated By Cadherin Cell-cell Adhesion
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Adherens junctions interactions
Drugs		Colforsin Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Atorvastatin-induced myopathy ( 31220337) Bipolar disorder ( 31043756 34002096 24618891) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Bipolar I disorder ( 31043756) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Capecitabine sensitivity ( 22864933) Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Food addiction ( 27106561) LDL cholesterol levels in HIV infection ( 33109212) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Oropharynx cancer ( 27749845) Pars opercularis volume ( 31530798) Plasma factor VII activating protease levels ( 30070759) Posterior-cingulate cortex volume ( 31530798) Smoking status (heavy vs never) ( 26423011) Visceral fat ( 22589738)	Childhood body mass index ( 33045005) Depression (quantitative trait) ( 20800221) Diabetes (gestational) ( 31269844) Erectile dysfunction ( 30583798) Metabolic coherence (transcriptomic) ( 30852652) Mitochondrial DNA levels ( 25240745) Obesity in adult survivors of childhood cancer exposed to cranial radiation ( 25963547) Obstetric antiphospholipid syndrome ( 28424481) Resistant hypertension ( 31545351) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Serum metabolite concentrations in chronic kidney disease ( 29545352) Type 2 diabetes ( 31049640)
Interacting Genes		14 interacting genes: ADCY1 ADCY5 AHRR CDH18 DRD4 F2RL1 GCDH GNAS GNG2 ISL1 NUF2 OBP2A RDH12 SLC9A3	5 interacting genes: ADCY2 CDH12 CDH6 CDH9 MYOG
Entrez ID		108	1016
HPRD ID		00052	04314
Ensembl ID		ENSG00000078295	ENSG00000145526
Uniprot IDs		Q08462 Q71UM8	D6RER2 Q13634
PDB IDs
Enriched GO Terms of Interacting Partners?		G Protein-coupled Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Secretion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Regulation Of Protein Transport G Protein-coupled Receptor Signaling Pathway Response To Ketone Cellular Response To Lipid CAMP Biosynthetic Process Adenylate Cyclase Activity Response To Alcohol Regulation Of Hormone Secretion Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Cellular Response To Forskolin Regulation Of Secretion By Cell Response To Forskolin Regulation Of Secretion Cellular Response To Catecholamine Stimulus Phosphorus-oxygen Lyase Activity Cellular Response To Prostaglandin E Stimulus Response To Catecholamine G-protein Beta-subunit Binding CAMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Response To Lipid Heterotrimeric G-protein Complex Regulation Of Biological Quality Nervous System Process Cyclic Purine Nucleotide Metabolic Process Regulation Of Protein Localization System Process Purine-containing Compound Biosynthetic Process Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Glutaryl-CoA Dehydrogenase Activity Positive Regulation Of Interleukin-1 Beta Production Nucleoside Phosphate Biosynthetic Process Calcium- And Calmodulin-responsive Adenylate Cyclase Activity Negative Regulation Of Protein Secretion Proteinase-activated Receptor Activity Positive Regulation Of Interleukin-1 Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Eosinophil Degranulation	Catenin Complex Cell-cell Adhesion Mediated By Cadherin Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Adherens Junction Organization Beta-catenin Binding Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Junction Assembly Cell-cell Junction Organization Cell Morphogenesis Adherens Junction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Synaptic Membrane Adhesion Cell Junction Assembly Cadherin Binding Cell Junction Organization Cell-cell Adhesion Calcium Ion Binding Positive Regulation Of Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Cell Adhesion Cell Migration Cell Motility Response To Denervation Involved In Regulation Of Muscle Adaptation Striated Muscle Atrophy Response To Muscle Inactivity Positive Regulation Of Skeletal Muscle Fiber Development Muscle Atrophy CAMP Biosynthetic Process Adenylate Cyclase Activity Regulation Of Skeletal Muscle Fiber Development Response To Inactivity Adenylate Cyclase Binding Regulation Of Skeletal Muscle Satellite Cell Proliferation Cellular Response To Forskolin Positive Regulation Of Myotube Differentiation Muscle Cell Fate Commitment Regulation Of Skeletal Muscle Cell Proliferation Cellular Response To Lithium Ion Response To Forskolin Response To Lithium Ion Phosphorus-oxygen Lyase Activity Anatomical Structure Morphogenesis Positive Regulation Of Skeletal Muscle Tissue Development CAMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Cellular Response To Lipid Positive Regulation Of Striated Muscle Tissue Development Regulation Of Myoblast Fusion Myotube Differentiation
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