GIPC1 and KCNJ6

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		GIPC1	KCNJ6
Description		GIPC PDZ domain containing family member 1	potassium inwardly rectifying channel subfamily J member 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Cytoplasmic Vesicle Dendritic Spine Dendritic Shaft Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Golgi Apparatus Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex
	Molecular Function	Actin Binding Signaling Receptor Binding Protein Binding Myosin Binding Identical Protein Binding Cadherin Binding	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity
	Biological Process	Protein Targeting G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Positive Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Cellular Response To Interleukin-7 Presynaptic Modulation Of Chemical Synaptic Transmission	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		FGFR1b ligand binding and activation FGFR1c ligand binding and activation TGFBR3 regulates TGF-beta signaling TGFBR3 regulates FGF2 signaling	Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Ethanol Halothane Ifenprodil Isavuconazole
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Kidney stones ( 31729369)	Body size at age 10 ( 32376654) Clostridioides difficle infection ( 33841421) Electroencephalographic traits in alcoholism ( 22554406) Response to placebo treatment in childhood asthma (FVC change) ( 31557306) Rosacea symptom severity ( 29771307)
Interacting Genes		38 interacting genes: ACTN1 ADRB1 BRD4 CARD10 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KCNJ6 KIF1B LHCGR LPAR1 LPAR2 LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 PLEKHA2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SLC2A1 TGFBR3 TPBG TYRP1 VANGL2 ZFPM1 ZNF408	71 interacting genes: ADRB2 AIG1 APOD BCL2L2 BET1 BIRC5 C14orf180 CMAS CMTM5 CNPY3 COL4A5 CXXC5 DLG1 DRD2 EDDM3B ERG28 FAM20B FIS1 FUNDC2 FXYD6 GABBR1 GIPC1 HMOX2 ICMT ITGAM KCNJ3 KCNJ9 LEPROTL1 LPAR3 LPCAT2 MAP1S MIP MYO15B NINJ2 ORMDL2 PEX11G PEX16 PICK1 PLLP PMP22 PNLIPRP1 PTPRD RPRM RPS6KA2 RTP2 SCAMP4 SCARF1 SCD SERTM1 STATH STRIT1 SYT3 THSD7B TM6SF2 TMEM107 TMEM120B TMEM203 TMEM208 TMEM218 TMPPE TNFRSF10C TSPO2 UBIAD1 UNC50 UPK1B VSTM1 XIAP YIPF1 YIPF6 ZBTB38 ZDHHC24
Entrez ID		10755	3763
HPRD ID		05462	02929
Ensembl ID		ENSG00000123159	ENSG00000157542
Uniprot IDs		A8K2I7 O14908	P48051
PDB IDs
Enriched GO Terms of Interacting Partners?		Plasma Membrane Glutamatergic Synapse Membrane Cell Migration Regulation Of Locomotion Regulation Of Signal Transduction Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Migration Receptor Complex Positive Regulation Of Signal Transduction Axon Regulation Of Cell Motility Cell Motility PDZ Domain Binding Cell Projection Organization Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Anatomical Structure Formation Involved In Morphogenesis Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Positive Regulation Of Nervous System Development Developmental Process Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Nervous System Development Positive Regulation Of Cellular Component Organization Endocytic Vesicle Positive Regulation Of Locomotion Dendrite Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Apoptotic Process Neural Tube Closure Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death Tube Closure Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Insulin-like Growth Factor I Binding Positive Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility	Membrane Presynaptic Membrane Trans-synaptic Signaling Synaptic Signaling Endoplasmic Reticulum Membrane Protein Binding Endoplasmic Reticulum Chemical Synaptic Transmission Negative Regulation Of Dopamine Secretion G-protein Activated Inward Rectifier Potassium Channel Activity Compact Myelin Inward Rectifier Potassium Channel Complex Regulation Of Sodium Ion Transport Protein Targeting Regulation Of Presynaptic Membrane Potential Regulation Of Monoatomic Ion Transport Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Golgi Trans Cisterna Negative Regulation Of Synaptic Transmission
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