PSMG1 and IDS

		PSMG1	IDS
Description		proteasome assembly chaperone 1	iduronate 2-sulfatase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Protein Folding Chaperone Complex	Lysosome Lysosomal Lumen
	Molecular Function	Protein Binding Molecular Adaptor Activity Proteasome Binding	Iduronate-2-sulfatase Activity Calcium Ion Binding Protein Binding Sulfuric Ester Hydrolase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Cerebellar Granule Cell Precursor Proliferation Proteasome Assembly Chaperone-mediated Protein Complex Assembly Proteasome Core Complex Assembly	Glycosaminoglycan Catabolic Process Heparan Sulfate Proteoglycan Catabolic Process Dermatan Sulfate Proteoglycan Catabolic Process Carbohydrate Derivative Catabolic Process
Pathways		Proteasome assembly Proteasome assembly	HS-GAG degradation CS/DS degradation MPS II - Hunter syndrome (HS-GAG degradation) MPS II - Hunter syndrome (CS/DS degradation)
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Diseases			Mucopolysaccharidosis type II (MPS2); Hunter syndrome
GWAS		Alanine aminotransferase levels ( 33547301) Ankylosing spondylitis ( 20062062) C-reactive protein levels ( 21300955) Daytime nap ( 33568662) Daytime sleep phenotypes ( 27126917) Eye morphology ( 29921221) Fibrinogen ( 23969696) Fibrinogen levels ( 26561523 28107422) Finger osteoarthritis severity (hand Klsum) ( 33055079) Glaucoma (primary open-angle) ( 33627673) Height ( 31562340) Inflammatory bowel disease ( 18758464) Pediatric autoimmune diseases ( 26301688) Primary sclerosing cholangitis ( 27992413 23603763) Serum alkaline phosphatase levels ( 33547301) Takayasu arteritis ( 23830517) Triglyceride levels ( 32203549) Ulcerative colitis ( 20228799)	Cognitive performance ( 20125193) Idiopathic downbeat nystagmus ( 32157568)
Interacting Genes		15 interacting genes: BRCA1 CEBPA CSDE1 GATD3 IDS PRKAR1A PRKAR1B PSMG2 RRP1 SNRNP70 SPRR2A SPTAN1 UBE2A UBE2G2 YME1L1	6 interacting genes: FTCD HTR6 IRAK1 LCOR PSMG1 RUNX1
Entrez ID		8624	3423
HPRD ID		05598	02402
Ensembl ID		ENSG00000183527	ENSG00000010404
Uniprot IDs		O95456	B4DGD7 P22304
PDB IDs		8QYJ 8QYL 8QYM 8QYN 8QYS 8QZ9 8TM3 8TM4 8TM5 8TM6 8YIX 8YIY 8YIZ	5FQL 6IOZ
Enriched GO Terms of Interacting Partners?		CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Cellular Response To Tumor Necrosis Factor Protein Kinase A Catalytic Subunit Binding Response To Tumor Necrosis Factor CAMP Binding Negative Regulation Of CAMP/PKA Signal Transduction Postreplication Repair Cellular Response To Cytokine Stimulus Ubiquitin Conjugating Enzyme Activity Regulation Of CAMP/PKA Signal Transduction Multivesicular Body Ciliary Base RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Iduronate-2-sulfatase Activity	Transcription Corepressor Binding Proteasome Core Complex Assembly Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity L-histidine Catabolic Process To Glutamate And Formate L-histidine Catabolic Process To Glutamate And Formamide
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