PAICS and USP30

Number of citations of the paper that reports this interaction (PubMedID 37848033)
0

Data Source:
BioGRID (enzymatic study)

		PAICS	USP30
Description		phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	ubiquitin specific peptidase 30
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GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Exosome	Nucleus Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Cytosol Membrane
	Molecular Function	Nucleotide Binding Catalytic Activity Phosphoribosylaminoimidazole Carboxylase Activity Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Protein Binding ATP Binding Lyase Activity Carboxy-lyase Activity Ligase Activity Identical Protein Binding Cadherin Binding	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Deubiquitinase Activity
	Biological Process	Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process 'de Novo' IMP Biosynthetic Process Purine Nucleobase Biosynthetic Process 'de Novo' AMP Biosynthetic Process 'de Novo' XMP Biosynthetic Process	Autophagy Of Mitochondrion Pexophagy Proteolysis Mitochondrial Fusion Protein Deubiquitination Regulation Of Protein Stability Protein K11-linked Deubiquitination Protein K6-linked Deubiquitination Negative Regulation Of Mitophagy
Pathways		Purine ribonucleoside monophosphate biosynthesis	Ub-specific processing proteases Pexophagy
Drugs		Aspartic acid
Diseases
GWAS			Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494)
Interacting Genes		27 interacting genes: ASB11 CDC37 CEBPA CEP76 CHD3 FXR1 FXR2 L3MBTL2 LCOR LINC00632 LNX1 MOB4 NIF3L1 NUDT18 PIAS2 PILRA PRKAG1 PTPRC RAD54L2 RNF4 SMARCD1 SNCA TERF1 UBE2I UBE3A USP30 ZMYM2	6 interacting genes: PAICS POLG PRKN RHBDD2 UBB UBC
Entrez ID		10606	84749
HPRD ID		01401	15633
Ensembl ID		ENSG00000128050	ENSG00000135093
Uniprot IDs		P22234	B3KUS5 Q70CQ3
PDB IDs		2H31 6YB8 6YB9 7ALE	5OHK 5OHN 5OHP 8D0A 8D1T
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process PML Body Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Postsynapse Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Macrophage Activation Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Catabolic Process Post-translational Protein Modification Protein Kinase Regulator Activity Regulation Of Synaptic Plasticity Positive Regulation Of Biosynthetic Process Translation Regulator Activity Positive Regulation Of Macromolecule Metabolic Process ATP-dependent Chromatin Remodeler Activity SUMO Transferase Activity Negative Regulation Of Transcription By RNA Polymerase II Protein Modification Process Protein Modification By Small Protein Conjugation Dentate Gyrus Development Modulation Of Chemical Synaptic Transmission Postsynaptic Cytosol Positive Regulation Of Protein Metabolic Process Response To Lipid RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Plasma Membrane Raft Distribution Transcription Coregulator Activity Response To Desipramine	Protein Tag Activity Mitochondrial Outer Membrane Proteolysis Involved In Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Protein Ubiquitination Negative Regulation Of Intralumenal Vesicle Formation Modification-dependent Protein Catabolic Process Regulation Of Mitochondrial Membrane Potential Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Membrane Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin ERAD Pathway Positive Regulation Of Protein Ubiquitination Mitochondrion Localization Proteolysis Macromolecule Catabolic Process Mitochondrion Regulation Of Signal Transduction By P53 Class Mediator DNA Replication Proofreading Mitochondrial Chromosome Gamma DNA Polymerase Complex Endocytic Vesicle Membrane Hypothalamus Gonadotrophin-releasing Hormone Neuron Development Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Phosphoribosylaminoimidazole Carboxylase Activity Protein Modification By Small Protein Conjugation Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Fusion Cellular Response To L-glutamine Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Lyase Activity Lewy Body Regulation Of Spontaneous Synaptic Transmission Regulation Of Proteasomal Protein Catabolic Process Type 2 Mitophagy Post-translational Protein Modification Regulation Of Protein Ubiquitination
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