PAICS

Description		phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
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GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Catalytic Activity Phosphoribosylaminoimidazole Carboxylase Activity Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Protein Binding ATP Binding Lyase Activity Carboxy-lyase Activity Ligase Activity Identical Protein Binding Cadherin Binding
	Biological Process	Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process 'de Novo' IMP Biosynthetic Process Purine Nucleobase Biosynthetic Process 'de Novo' AMP Biosynthetic Process 'de Novo' XMP Biosynthetic Process
Pathways		Purine ribonucleoside monophosphate biosynthesis
Drugs		Aspartic acid
Diseases
GWAS
Novel Interacting Genes		27 novel interacting genes: ASB11 CDC37 CEBPA CEP76 CHD3 FXR1 FXR2 L3MBTL2 LCOR LINC00632 LNX1 MOB4 NIF3L1 NUDT18 PIAS2 PILRA PRKAG1 PTPRC RAD54L2 RNF4 SMARCD1 SNCA TERF1 UBE2I UBE3A USP30 ZMYM2
Interacting Genes		27 interacting genes: ASB11 CDC37 CEBPA CEP76 CHD3 FXR1 FXR2 L3MBTL2 LCOR LINC00632 LNX1 MOB4 NIF3L1 NUDT18 PIAS2 PILRA PRKAG1 PTPRC RAD54L2 RNF4 SMARCD1 SNCA TERF1 UBE2I UBE3A USP30 ZMYM2
Entrez ID		10606
HPRD ID		01401
Ensembl ID		ENSG00000128050
Uniprot IDs		P22234
PDB IDs		2H31 6YB8 6YB9 7ALE
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process PML Body Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Postsynapse Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Macrophage Activation Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Catabolic Process Post-translational Protein Modification Protein Kinase Regulator Activity Regulation Of Synaptic Plasticity Positive Regulation Of Biosynthetic Process Translation Regulator Activity Positive Regulation Of Macromolecule Metabolic Process ATP-dependent Chromatin Remodeler Activity SUMO Transferase Activity Negative Regulation Of Transcription By RNA Polymerase II Protein Modification Process Protein Modification By Small Protein Conjugation Dentate Gyrus Development Modulation Of Chemical Synaptic Transmission Postsynaptic Cytosol Positive Regulation Of Protein Metabolic Process Response To Lipid RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Plasma Membrane Raft Distribution Transcription Coregulator Activity Response To Desipramine
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