DRAP1 and FEZ1

Number of citations of the paper that reports this interaction (PubMedID 16484223)
0

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vitro, two hybrid)

		DRAP1	FEZ1
Description		DR1 associated protein 1	fasciculation and elongation protein zeta 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Negative Cofactor 2 Complex RNA Polymerase II Transcription Regulator Complex	Cytoplasm Golgi Apparatus Centrosome Cytoskeleton Microtubule Plasma Membrane Membrane Axon Dendrite Growth Cone Cell Projection Neuronal Cell Body
	Molecular Function	Core Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Identical Protein Binding Protein Heterodimerization Activity	Protein Kinase C Binding Protein Binding Gamma-tubulin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II	Mitochondrion Organization Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Hippocampus Development Establishment Of Cell Polarity Establishment Of Mitochondrion Localization Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Cellular Response To Growth Factor Stimulus Negative Regulation Of Autophagosome Assembly
Pathways		Signaling by NODAL Signaling by Activin
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Asthma ( 31959851) Eosinophil percentage of granulocytes ( 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Severe influenza A (H1N1) infection ( 26379185)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Breast cancer (survival) ( 25890600) Schizophrenia ( 22688191 23894747)
Interacting Genes		31 interacting genes: APP ARHGEF10L CDKN2C DNAJB11 DR1 FBXO7 FEZ1 FEZ2 FOXH1 GTF2B LMO2 LNX1 LNX2 MCRS1 MORF4L1 NCK2 NFYB PICK1 PIK3R3 PLEKHF2 POLE3 RPL9 SDCBP SRPK2 TAF9 TAF9B TBP TK1 TNFRSF14 TTF2 ZEB1	60 interacting genes: BARD1 BORA BRD1 C8orf33 CCL7 CEP126 CIB1 CLASP2 COL9A2 CSTF2 DIS3L2 DISC1 DNAAF5 DRAP1 DYRK1A FEZ2 GEMIN7 GTF2F1 HAP1 HTATSF1 HTT IMMT LRIF1 MEST NBR1 NDUFB9 NEK1 NRIP1 OLFML3 P4HB PAM16 PCNT PDCD7 PPP4R3B PRKCZ PTH PTN PTPRS RAB3GAP1 RAB3GAP2 RAI14 RIF1 SAP30L SCOC SERPINH1 SMARCD1 SMC3 STAR TAC3 TAF1D TAF9 TBC1D25 TEDC2 TLK2 TOMM20 TTR TXNDC9 UBE4B WWC1 ZNF251
Entrez ID		10589	9638
HPRD ID		03796	09212
Ensembl ID		ENSG00000175550	ENSG00000149557
Uniprot IDs		Q14919	Q99689
PDB IDs		1JFI
Enriched GO Terms of Interacting Partners?		RNA Polymerase II General Transcription Initiation Factor Activity Protein Heterodimerization Activity Transcription Factor TFIID Complex DNA-binding Transcription Factor Binding RNA Polymerase II Preinitiation Complex Assembly Transcription Preinitiation Complex Assembly DNA-templated Transcription Initiation Regulation Of Intrinsic Apoptotic Signaling Pathway Protein-DNA Complex Assembly Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Protein-containing Complex Assembly Regulation Of Cellular Response To Stress Regulation Of Receptor Internalization Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II ATAC Complex Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Autophagosome Assembly Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Nucleic Acid Metabolic Process Transcription Factor TFTC Complex Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein-containing Complex Organization Chromatin Organization Regulation Of Apoptotic Signaling Pathway RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Metabolic Process Cytoskeletal Anchor Activity Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Remodeling TBP-class Protein Binding Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Receptor Internalization BHLH Transcription Factor Binding Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Transcription Cis-regulatory Region Binding Positive Regulation Of Macromolecule Metabolic Process	Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Autophagosome Microtubule Cytoskeleton Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Regulation Of Cellular Response To Stress Centrosome Regulation Of Macroautophagy Microtubule Cytoskeleton Organization Involved In Mitosis Microtubule-based Process Positive Regulation Of Protein Lipidation Cytoskeleton Regulation Of Endoplasmic Reticulum Tubular Network Organization RNA Polymerase II General Transcription Initiation Factor Binding Regulation Of Protein Lipidation Regulation Of Organelle Assembly Regulation Of Microtubule-based Process RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of Macroautophagy Positive Regulation Of Organelle Assembly Regulation Of Autophagy Microtubule Organizing Center Mitotic Spindle Organization Axon Negative Regulation Of Microtubule Polymerization Or Depolymerization Chondroitin Sulfate Binding Regulation Of Autophagosome Assembly Regulation Of Organelle Organization
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