OLFM4 and TMEM130

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OLFM4	TMEM130
Description		olfactomedin 4	transmembrane protein 130
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Mitochondrion Cytosol Plasma Membrane Secretory Granule Protein-containing Complex Specific Granule Lumen Specific Granule Azurophil Granule Intercellular Bridge Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Lumen	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Cadherin Binding	Protein Binding
	Biological Process	Immune Response Cell Adhesion Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Immune Response Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 29381148 24861553 25673413 25953783 28448500 26961502) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body size at age 10 ( 32376654) Cerebrospinal P-tau181p levels ( 28247064) Childhood body mass index ( 26604143) Depression ( 29700475) Hip circumference ( 25673412) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Major depressive disorder ( 27479909) Multisite chronic pain ( 33830993) Obesity ( 23563607 22484627) Obesity-related traits ( 23251661) Waist circumference ( 25673412)	Decreased low contrast letter acuity in multiple sclerosis ( 31289819)
Interacting Genes		39 interacting genes: APP AQP2 AQP3 BSCL2 C3 CFTR CLDN7 CLEC17A CLEC7A CLSTN3 CLTRN CREB3L1 EREG FAM209A FNDC9 IL11RA ITM2C KASH5 KIR2DL3 KIR3DL3 LDLRAD1 LEUTX LHFPL2 PCDH17 PRR20A PRR20B PVR PVRIG QPCTL SAR1A SLC18A1 SLC22A23 SUSD3 SYNE4 TFR2 TMEM130 TNFSF11 TNFSF14 TSPAN18	10 interacting genes: GRM2 NKG7 OLFM4 PIGF SLC2A5 SLC35B4 SLC61A1 TMEM100 TSPAN2 YIPF6
Entrez ID		10562	222865
HPRD ID		06580	13226
Ensembl ID		ENSG00000102837	ENSG00000166448
Uniprot IDs		Q6UX06	Q8N3G9
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Receptor Ligand Activity Multicellular Organismal-level Chemical Homeostasis Water Transport Multicellular Organismal-level Water Homeostasis Fluid Transport Glycerol Transmembrane Transport Multicellular Organismal-level Homeostasis Renal Water Transport Polyol Transmembrane Transport Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Yeast Cell Maturation Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Neuron Remodeling Water Channel Activity Organic Hydroxy Compound Transport Positive Regulation Of Defense Response Cell Surface Regulation Of Immune System Process Renal Water Homeostasis	Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Fructose Import Across Plasma Membrane UDP-xylose Transmembrane Transport UDP-xylose Transmembrane Transporter Activity Molybdate Ion Transmembrane Transporter Activity Molybdate Ion Transport Organic Anion Transport Group II Metabotropic Glutamate Receptor Activity Membrane Ethanolaminephosphotransferase Activity Microglia Development UDP-N-acetylglucosamine Transmembrane Transporter Activity UDP-N-acetylglucosamine Transmembrane Transport
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