PPIH and PRPF18

Number of citations of the paper that reports this interaction (PubMedID 11823439)
37

Data Source:
HPRD (in vitro, in vivo)

		PPIH	PRPF18
Description		peptidylprolyl isomerase H	pre-mRNA processing factor 18
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Nuclear Speck Intracellular Membrane-bounded Organelle U4/U6 X U5 Tri-snRNP Complex U4/U6 SnRNP	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Post-spliceosomal Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Cyclosporin A Binding Isomerase Activity Ribonucleoprotein Complex Binding	Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Protein Folding RNA Splicing Positive Regulation Of Viral Genome Replication Protein-containing Complex Assembly	Generation Of Catalytic Spliceosome For Second Transesterification Step MRNA Processing RNA Splicing
Pathways		mRNA Splicing - Major Pathway SARS-CoV-1 activates/modulates innate immune responses	mRNA Splicing - Major Pathway
Drugs		Proline
Diseases
GWAS			Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) ( 24025145) Craniofacial microsomia ( 26853712) Lupus nephritis in systemic lupus erythematosus ( 24925725) Post bronchodilator FEV1/FVC ratio ( 26634245) Skin pigmentation ( 28300201)
Interacting Genes		16 interacting genes: BAG2 BPIFA1 CEBPA DOK3 IPO13 KDM4A LNX1 LNX2 N4BP2L2 NIF3L1 PRPF18 PRPF31 PRPF4 SNU13 UBQLN2 XIAP	81 interacting genes: AGTRAP AMOTL2 AP2M1 ASCC2 BEGAIN BICD2 BLZF1 CADPS CALCOCO2 CARD10 CARD9 CBY2 CCDC102B CCDC136 CCDC150 CCDC57 CCNC CDR2 CEP70 CSRNP1 DRC4 DVL3 EFHC2 EVI5L FERMT3 FSD2 GCC1 GOLGA2 GOLGA6L9 GPBP1 GRIPAP1 HMBOX1 HOMEZ HOOK2 HSF2BP IKBKG IKZF1 KANK2 KCTD7 KIFC3 KRT31 KRT34 KRT35 KRT39 KRT40 LDOC1 LZTS1 LZTS2 MCC MDFI MEOX2 MTUS2 NACC1 NECAB2 NINL NUTM1 NUTM2F OSBPL3 PDE9A PFDN5 PIBF1 PICK1 PLEKHG4 PNMA1 PPIH PRKAR1B RHOU RINT1 SCHIP1 SPRED1 STX11 TFIP11 TRAF2 TRIM23 TRIM27 TRIM54 TSNAX TSNAXIP1 UBXN11 ZNF526 ZNF639
Entrez ID		10465	8559
HPRD ID		12084	05407
Ensembl ID		ENSG00000171960	ENSG00000165630
Uniprot IDs		O43447 Q6FH36	Q99633
PDB IDs		1MZW 1QOI 5O9Z 6AHD 8H6K 8H6L 8QO9 8QZS 8R09 8R0B 8RM5	2DK4
Enriched GO Terms of Interacting Partners?		U4/U6 X U5 Tri-snRNP Complex U4 SnRNA Binding U4atac SnRNP U4atac SnRNA Binding U2-type Precatalytic Spliceosome Spliceosomal Complex Identical Protein Binding Regulation Of Hematopoietic Stem Cell Proliferation Precatalytic Spliceosome Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process RNA Splicing Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Protein Catabolic Process MRNA Splicing, Via Spliceosome MRNA Processing Protein-RNA Complex Assembly Box C/D Sno(s)RNA Binding RNA Splicing, Via Transesterification Reactions U2-type Post-spliceosomal Complex Histone H3K36me2/H3K36me3 Demethylase Activity Ribonucleoprotein Complex Localization Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Apoptosis Involved In Tissue Homeostasis Ubiquitin-protein Transferase Activity Response To Vitamin B2 C/EBP Complex Dense Fibrillar Component Generation Of Catalytic Spliceosome For Second Transesterification Step Cajal Body Negative Regulation Of G Protein-coupled Receptor Internalization Immune Response In Nasopharyngeal-associated Lymphoid Tissue Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism MRNA Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Regulation Of Stem Cell Proliferation U4/U6 SnRNP Dendritic Microtubule SnRNP Binding PDZ Domain Binding White Fat Cell Proliferation Spliceosomal SnRNP Complex Histone H3K9me2/H3K9me3 Demethylase Activity Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Clathrin-dependent Endocytosis Immune Response In Gut-associated Lymphoid Tissue Regulation Of Protein Catabolic Process	Protein Binding Cytoplasm Cytoskeleton Structural Constituent Of Skin Epidermis Intermediate Filament Organization Microtubule Identical Protein Binding Cytoskeleton Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process A2A Adenosine Receptor Binding Organelle Organization CBM Complex Cytosol Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
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