PPIH and N4BP2L2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PPIH	N4BP2L2
Description		peptidylprolyl isomerase H	NEDD4 binding protein 2 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Nuclear Speck Intracellular Membrane-bounded Organelle U4/U6 X U5 Tri-snRNP Complex U4/U6 SnRNP	Nucleus Transcription Repressor Complex Extracellular Exosome
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Cyclosporin A Binding Isomerase Activity Ribonucleoprotein Complex Binding	Transcription Corepressor Activity Protein Binding Enzyme Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Protein Folding RNA Splicing Positive Regulation Of Viral Genome Replication Protein-containing Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Blastocyst Development Positive Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		mRNA Splicing - Major Pathway SARS-CoV-1 activates/modulates innate immune responses
Drugs		Proline
Diseases
GWAS			Adult body size ( 32376654) Breast cancer ( 23535729) Coronary artery disease ( 29212778 33020668) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Logical memory (delayed recall) ( 29274321) Myocardial infarction ( 33532862)
Interacting Genes		16 interacting genes: BAG2 BPIFA1 CEBPA DOK3 IPO13 KDM4A LNX1 LNX2 N4BP2L2 NIF3L1 PRPF18 PRPF31 PRPF4 SNU13 UBQLN2 XIAP	8 interacting genes: EXOSC8 HOXA1 HUNK LMO2 NAA38 PPIA PPIH PPIL1
Entrez ID		10465	10443
HPRD ID		12084	15119
Ensembl ID		ENSG00000171960	ENSG00000244754
Uniprot IDs		O43447 Q6FH36	A0A6I8PRE0 A0A6I8PRM1 A0A6I8PRR0 A0A6I8PS46 B4DPY1 Q6ZV26 Q92802
PDB IDs		1MZW 1QOI 5O9Z 6AHD 8H6K 8H6L 8QO9 8QZS 8R09 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		U4/U6 X U5 Tri-snRNP Complex U4 SnRNA Binding U4atac SnRNP U4atac SnRNA Binding U2-type Precatalytic Spliceosome Spliceosomal Complex Identical Protein Binding Regulation Of Hematopoietic Stem Cell Proliferation Precatalytic Spliceosome Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process RNA Splicing Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Protein Catabolic Process MRNA Splicing, Via Spliceosome MRNA Processing Protein-RNA Complex Assembly Box C/D Sno(s)RNA Binding RNA Splicing, Via Transesterification Reactions U2-type Post-spliceosomal Complex Histone H3K36me2/H3K36me3 Demethylase Activity Ribonucleoprotein Complex Localization Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Apoptosis Involved In Tissue Homeostasis Ubiquitin-protein Transferase Activity Response To Vitamin B2 C/EBP Complex Dense Fibrillar Component Generation Of Catalytic Spliceosome For Second Transesterification Step Cajal Body Negative Regulation Of G Protein-coupled Receptor Internalization Immune Response In Nasopharyngeal-associated Lymphoid Tissue Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism MRNA Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Regulation Of Stem Cell Proliferation U4/U6 SnRNP Dendritic Microtubule SnRNP Binding PDZ Domain Binding White Fat Cell Proliferation Spliceosomal SnRNP Complex Histone H3K9me2/H3K9me3 Demethylase Activity Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Clathrin-dependent Endocytosis Immune Response In Gut-associated Lymphoid Tissue Regulation Of Protein Catabolic Process	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Peptidyl-prolyl Isomerization Cyclosporin A Binding Isomerase Activity Protein Folding Positive Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Semicircular Canal Formation Regulation Of Viral Genome Replication Abducens Nerve Formation Optokinetic Behavior Negative Regulation Of Protein K48-linked Ubiquitination NatC Complex Regulation Of Viral Life Cycle Cell Adhesion Molecule Production U4/U6 SnRNP U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Regulation Of Viral Process MRNA Metabolic Process Outer Ear Morphogenesis Embryonic Neurocranium Morphogenesis Virion Binding Regulation Of Protein K48-linked Ubiquitination Activation Of Protein Kinase B Activity Negative Regulation Of Viral Life Cycle Endothelial Cell Activation Heparan Sulfate Binding Negative Regulation Of Protein Polyubiquitination Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Stress-activated MAPK Cascade MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Splicing, Via Transesterification Reactions Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) U4 SnRNA 3'-end Processing Nuclear Polyadenylation-dependent RRNA Catabolic Process TRNA Decay Nuclear MRNA Surveillance Nucleus RNA Processing Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RRNA Catabolic Process Nuclear Exosome (RNase Complex)
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