SYCP3 and NR2F2

		SYCP3	NR2F2
Description		synaptonemal complex protein 3	nuclear receptor subfamily 2 group F member 2
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Synaptonemal Complex Lateral Element Nucleus Chromosome	Nucleus Nucleoplasm Cytosol
	Molecular Function	DNA Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Retinoic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Male Meiosis I Spermatid Development Sperm DNA Condensation Cell Division Meiotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Neuron Migration Maternal Placenta Development Negative Regulation Of Endothelial Cell Proliferation Lymph Vessel Development Positive Regulation Of Systemic Arterial Blood Pressure Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Skeletal Muscle Tissue Development Female Gonad Development Fertilization Anterior/posterior Pattern Specification Radial Pattern Formation Negative Regulation Of Endothelial Cell Migration Cell Differentiation Intracellular Receptor Signaling Pathway Forebrain Development Response To Estradiol Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Lymphatic Endothelial Cell Fate Commitment Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Interneuron Migration
Pathways		Meiotic synapsis	Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases		Azoospermia, including: Azoospermia; Azoospermia due to perturbations of meiosis
GWAS		Brain morphology (MOSTest) ( 32665545)	Adventurousness ( 30643258) Birth weight ( 31043758) Cannabis use ( 27023175) Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia ( 29274321) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphangioleiomyomatosis (sporadic) ( 31000673) Metabolite levels ( 23823483) Motion sickness ( 25628336) Optic disc area ( 25631615) Optic disc size ( 31809533) Photic sneeze reflex ( 27182965) PR interval ( 32439900) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Serum alkaline phosphatase levels ( 33547301) Sex hormone-binding globulin levels ( 22829776) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659)
Interacting Genes		7 interacting genes: C14orf119 CDC37 LIG4 NR2F2 NXF1 PABPC1 SYCP2	24 interacting genes: BCL11A BCL11B BIK CHD2 EP300 FOXP1 FOXP2 FOXP4 HDAC1 HIPK3 MYOD1 NCOR2 NR2F6 NR3C1 NSD1 PHB2 PIAS1 RLBP1 SETD7 SQSTM1 SYCP3 TENT5A TRIM24 TRIP4
Entrez ID		50511	7026
HPRD ID		07265	00139
Ensembl ID		ENSG00000139351	ENSG00000185551
Uniprot IDs		Q8IZU3	F1D8R0 P24468
PDB IDs		4CPC	3CJW
Enriched GO Terms of Interacting Partners?		Establishment Of Integrated Proviral Latency DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Fertilization Lymphatic Endothelial Cell Fate Commitment Radial Pattern Formation Male Genitalia Morphogenesis Cytoplasmic Stress Granule HSP90-CDC37 Chaperone Complex Double-strand Break Repair Via Classical Nonhomologous End Joining Lymphoid Progenitor Cell Differentiation Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development DNA-dependent Protein Kinase-DNA Ligase 4 Complex Single Strand Break Repair Immunoglobulin V(D)J Recombination AMP Binding Chordate Embryonic Development Nonhomologous End Joining Complex Nucleotide-excision Repair, DNA Gap Filling In Utero Embryonic Development Lymph Vessel Development Maternal Placenta Development Trophoblast Giant Cell Differentiation Epithelial Cell Fate Commitment Genitalia Morphogenesis Lateral Element Nuclear RNA Export Factor Complex Nuclear Inclusion Body MRNA Binding Transcription Export Complex Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Positive Regulation Of Type 2 Mitophagy Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Translation Activator Activity MCRD-mediated MRNA Stability Complex Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay CRD-mediated MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Response To Lithium Ion Interneuron Migration Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway	Negative Regulation Of RNA Metabolic Process Nuclear Receptor Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Chromatin Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process DNA Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Sequence-specific DNA Binding Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Zinc Ion Binding Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity P53 Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Androgen Receptor Binding Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Chromatin Organization Macromolecule Biosynthetic Process Negative Regulation Of Protein Oligomerization Regulation Of Programmed Cell Death
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