NMUR1 and GIGYF2

		NMUR1	GIGYF2
Description		neuromedin U receptor 1	GRB10 interacting GYF protein 2
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GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane	Cytoplasm Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoplasmic Stress Granule Membrane Vesicle Protein-containing Complex Perikaryon Proximal Dendrite
	Molecular Function	Neuromedin U Receptor Activity G Protein-coupled Receptor Activity Neuropeptide Receptor Activity Neuromedin U Binding	RNA Binding Protein Binding Cadherin Binding Molecular Adaptor Activity Proline-rich Region Binding
	Biological Process	Chloride Transport Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Calcium-mediated Signaling Positive Regulation Of Calcium-mediated Signaling	Feeding Behavior Adult Locomotory Behavior Post-embryonic Development Post-transcriptional Gene Silencing Negative Regulation Of Translation Spinal Cord Motor Neuron Differentiation Mitotic G1 DNA Damage Checkpoint Signaling Multicellular Organism Growth Negative Regulation Of Translational Initiation Insulin-like Growth Factor Receptor Signaling Pathway Homeostasis Of Number Of Cells Within A Tissue Musculoskeletal Movement Neuromuscular Process Controlling Balance Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization Rescue Of Stalled Ribosome
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs
Diseases			Parkinson's disease (PD)
GWAS		Corneal astigmatism ( 30306274) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Anxiety and stress-related disorders ( 31116379) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Hip circumference adjusted for BMI ( 34021172) Myocardial infarction ( 33532862) Schizophrenia ( 23974872 25056061 29483656)
Interacting Genes		3 interacting genes: GIGYF2 NMS NMU	18 interacting genes: APC ARL4C ATG16L1 CAB39 CNOT9 CRYAA EPHA2 GRB10 GRB14 GRB7 METTL21A NMUR1 RBM12 RNF10 SNRPB UBC USP7 WBP11
Entrez ID		10316	26058
HPRD ID		16039	11639
Ensembl ID		ENSG00000171596	ENSG00000204120
Uniprot IDs		Q9HB89	Q6Y7W6
PDB IDs		7W53 7W56	5NVL 5NVM 7RUP
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Neuromedin U Receptor Binding Type 2 Neuromedin U Receptor Binding Negative Regulation Of Gastric Emptying Positive Regulation Of Stomach Fundus Smooth Muscle Contraction Feeding Behavior Type 1 Neuromedin U Receptor Binding Positive Regulation Of Prolactin Secretion Regulation Of Grooming Behavior Negative Regulation Of Eating Behavior Negative Regulation Of Gastric Acid Secretion Positive Regulation Of Sensory Perception Of Pain Regulation Of Gastric Motility Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Regulation Of Eating Behavior Gastric Acid Secretion Regulation Of Gastric Acid Secretion Negative Regulation Of Feeding Behavior Proximal Dendrite Positive Regulation Of Heat Generation Positive Regulation Of Systemic Arterial Blood Pressure Multicellular Organismal-level Homeostasis Mitotic G1 DNA Damage Checkpoint Signaling Musculoskeletal Movement Mitotic G1/S Transition Checkpoint Signaling Proline-rich Region Binding Regulation Of Sensory Perception Of Pain Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Type I Interferon-mediated Signaling Pathway Spinal Cord Motor Neuron Differentiation Regulation Of Circadian Sleep/wake Cycle Acid Secretion Regulation Of Feeding Behavior Positive Regulation Of Heart Rate Photoperiodism Positive Regulation Of Smooth Muscle Contraction Eating Behavior Positive Regulation Of Blood Pressure G Protein-coupled Receptor Signaling Pathway Temperature Homeostasis Terminal Bouton Positive Regulation Of Heart Contraction Cell Differentiation In Spinal Cord Homeostasis Of Number Of Cells Within A Tissue Insulin-like Growth Factor Receptor Signaling Pathway Rescue Of Stalled Ribosome Regulation Of Type I Interferon-mediated Signaling Pathway Ribosome Disassembly Negative Regulation Of Translational Initiation Neuromuscular Process Controlling Balance	Insulin Receptor Signaling Pathway Lens Fiber Cell Morphogenesis Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Leading Edge Membrane Cytosol Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein-containing Complex Cytoplasm Enzyme-linked Receptor Protein Signaling Pathway Protein Methylation
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