GIGYF2 and ARL4C

		GIGYF2	ARL4C
Description		GRB10 interacting GYF protein 2	ARF like GTPase 4C
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoplasmic Stress Granule Membrane Vesicle Protein-containing Complex Perikaryon Proximal Dendrite	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Filopodium Cell Projection
	Molecular Function	RNA Binding Protein Binding Cadherin Binding Molecular Adaptor Activity Proline-rich Region Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Alpha-tubulin Binding
	Biological Process	Feeding Behavior Adult Locomotory Behavior Post-embryonic Development Post-transcriptional Gene Silencing Negative Regulation Of Translation Spinal Cord Motor Neuron Differentiation Mitotic G1 DNA Damage Checkpoint Signaling Multicellular Organism Growth Negative Regulation Of Translational Initiation Insulin-like Growth Factor Receptor Signaling Pathway Homeostasis Of Number Of Cells Within A Tissue Musculoskeletal Movement Neuromuscular Process Controlling Balance Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization Rescue Of Stalled Ribosome	Intracellular Protein Transport Endocytic Recycling
Pathways			NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases		Parkinson's disease (PD)
GWAS		Anxiety and stress-related disorders ( 31116379) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Hip circumference adjusted for BMI ( 34021172) Myocardial infarction ( 33532862) Schizophrenia ( 23974872 25056061 29483656)	Blood pressure measurement (high sodium and potassium intervention) ( 24165912) Central corneal thickness ( 29760442) Cognitive decline (age-related) ( 28078323) Initial pursuit acceleration in psychotic disorders ( 29064472) Pancreatic cancer ( 20686608) Systolic blood pressure x educational attainment (some college) interaction (2df) ( 32372009) Triglyceride levels ( 30108155)
Interacting Genes		18 interacting genes: APC ARL4C ATG16L1 CAB39 CNOT9 CRYAA EPHA2 GRB10 GRB14 GRB7 METTL21A NMUR1 RBM12 RNF10 SNRPB UBC USP7 WBP11	3 interacting genes: APP GIGYF2 UBQLN4
Entrez ID		26058	10123
HPRD ID		11639	11988
Ensembl ID		ENSG00000204120	ENSG00000188042
Uniprot IDs		Q6Y7W6	P56559
PDB IDs		5NVL 5NVM 7RUP
Enriched GO Terms of Interacting Partners?		Insulin Receptor Signaling Pathway Lens Fiber Cell Morphogenesis Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Leading Edge Membrane Cytosol Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein-containing Complex Cytoplasm Enzyme-linked Receptor Protein Signaling Pathway Protein Methylation	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Adult Locomotory Behavior Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Adult Behavior Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Protein-containing Complex Lipoprotein Particle Perikaryon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Locomotory Behavior Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Cellular Response To Norepinephrine Stimulus Endoplasmic Reticulum Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Cytosolic Proteasome Complex Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Developmental Growth Regulation Of Proteolysis Regulation Of Protein Catabolic Process Heparan Sulfate Binding Signaling Receptor Activator Activity Proximal Dendrite Peptidase Activator Activity Cellular Response To Manganese Ion
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