KATNB1 and DYNC1H1

Number of citations of the paper that reports this interaction (PubMedID 16203747)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)

		KATNB1	DYNC1H1
Description		katanin regulatory subunit B1	dynein cytoplasmic 1 heavy chain 1
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Katanin Complex Microtubule Cytoskeleton Membrane Axon Growth Cone Midbody Neuronal Cell Body	Extracellular Region Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Cell Cortex Membrane Filopodium Dynein Complex Azurophil Granule Lumen Extracellular Exosome Axon Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding Protein Heterodimerization Activity ATPase Regulator Activity Dynein Complex Binding	Nucleotide Binding RNA Binding Protein Binding ATP Binding Minus-end-directed Microtubule Motor Activity Identical Protein Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Protein Targeting Microtubule Depolymerization Negative Regulation Of Microtubule Depolymerization Mitotic Chromosome Movement Towards Spindle Pole Positive Regulation Of Neuron Projection Development Positive Regulation Of Microtubule Depolymerization Cytoplasmic Microtubule Organization Positive Regulation Of Apoptotic Process Microtubule Severing Cell Division	Microtubule-based Movement Mitotic Spindle Organization Nuclear Migration Retrograde Axonal Transport Cytoplasmic Microtubule Organization Positive Regulation Of Intracellular Transport P-body Assembly Stress Granule Assembly Establishment Of Spindle Localization Cell Division Regulation Of Mitotic Spindle Organization Regulation Of Metaphase Plate Congression Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Spindle Assembly
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases			Distal hereditary motor neuropathies (dHMN)
GWAS			Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)
Interacting Genes		7 interacting genes: CAMSAP3 DYNC1H1 KATNA1 PAFAH1B1 RXFP3 TGFBR1 XRN1	34 interacting genes: ASB7 ATP2B3 BRCA1 BTG3 CEBPA COX20 DISC1 DSCAM DSCR9 DUX4 DYNLL1 ECSIT EGFR FILNC1 ITSN1 KATNA1 KATNB1 LINC01554 LMO4 MRE11 MTNR1B NDEL1 PPP2R5C PRKCD PSMB9 RHBDD2 SMAD2 SORBS2 SUMO2 TENT5A TNIK YWHAG YWHAQ ZBTB42
Entrez ID		10300	1778
HPRD ID		04081	02524
Ensembl ID		ENSG00000140854	ENSG00000197102
Uniprot IDs		Q9BVA0	Q14204
PDB IDs			5NUG 5OWO 6F1T 6F1U 6F1V 6F1Y 6F38 6F3A 7Z8F 7Z8G 7Z8H 7Z8I 7Z8J 7Z8K 7Z8L 8DYU 8DYV 8FCY 8FD6 8FDT 8FDU 8PQV 8PQW 8PQY 8PQZ 8PR0 8PR1 8PR2 8PR3 8PTK
Enriched GO Terms of Interacting Partners?		Cytoplasmic Microtubule Organization Microtubule Retrograde Axonal Transport Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cytoskeleton Organization Microtubule Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Cell Cycle Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Nuclear Migration Nucleus Localization Microtubule-based Transport Centrosome Dynein Intermediate Chain Binding Microtubule Binding Microtubule Cytoskeleton Regulation Of Microtubule-based Process Microtubule-based Process Establishment Of Spindle Localization Cytoplasmic Microtubule Positive Regulation Of Cell Cycle Axon Cytoplasm Spindle Localization Axonal Transport Cytoskeleton Organization Microtubule-based Movement Cellular Response To Puromycin Cellular Response To Cycloheximide Axo-dendritic Transport Cell Division Supramolecular Fiber Organization Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Regulation Of Cellular Component Organization Microtubule Cytoskeleton Organization Involved In Mitosis Microtubule Sliding 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Astral Microtubule Ameboidal-type Cell Migration Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Central Region Of Growth Cone Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Replication Fork Protection Complex Zonula Adherens Maintenance Negative Regulation Of DNA Metabolic Process Cytoskeleton Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation	Intracellular Signal Transduction DNA Strand Resection Involved In Replication Fork Processing BRCA1-C Complex Cerebral Cortex Cell Migration Katanin Complex Radial Glia-guided Pyramidal Neuron Migration Telencephalon Cell Migration Signal Transduction Forebrain Cell Migration Microtubule Severing
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