DYNC1H1 and TENT5A

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)

		DYNC1H1	TENT5A
Description		dynein cytoplasmic 1 heavy chain 1	terminal nucleotidyltransferase 5A
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Cell Cortex Membrane Filopodium Dynein Complex Azurophil Granule Lumen Extracellular Exosome Axon Cytoplasm	Cytoplasm
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding Minus-end-directed Microtubule Motor Activity Identical Protein Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	RNA Binding Protein Binding Transferase Activity Nucleotidyltransferase Activity Poly(A) RNA Polymerase Activity
	Biological Process	Microtubule-based Movement Mitotic Spindle Organization Nuclear Migration Retrograde Axonal Transport Cytoplasmic Microtubule Organization Positive Regulation Of Intracellular Transport P-body Assembly Stress Granule Assembly Establishment Of Spindle Localization Cell Division Regulation Of Mitotic Spindle Organization Regulation Of Metaphase Plate Congression Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Spindle Assembly	Response To Bacterium Regulation Of Ossification Positive Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation MRNA Stabilization
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases		Distal hereditary motor neuropathies (dHMN)
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)	Appendicular lean mass ( 33097823)
Interacting Genes		34 interacting genes: ASB7 ATP2B3 BRCA1 BTG3 CEBPA COX20 DISC1 DSCAM DSCR9 DUX4 DYNLL1 ECSIT EGFR FILNC1 ITSN1 KATNA1 KATNB1 LINC01554 LMO4 MRE11 MTNR1B NDEL1 PPP2R5C PRKCD PSMB9 RHBDD2 SMAD2 SORBS2 SUMO2 TENT5A TNIK YWHAG YWHAQ ZBTB42	32 interacting genes: ARID5A ATXN1 BAG6 BCCIP BHLHE40 CD93 COL4A2 DMRTB1 DYNC1H1 EGLN2 GLIS2 HDLBP HTRA1 HYPK KEAP1 KRTAP26-1 NR2F2 PSG3 RHOXF2 RIN3 RNF14 RNF44 ROR2 SNRPC SPINT1 TBX4 TENT5B TNS2 TOLLIP YPEL3 ZC3H10 ZFYVE9
Entrez ID		1778	55603
HPRD ID		02524	13311
Ensembl ID		ENSG00000197102	ENSG00000112773
Uniprot IDs		Q14204	Q96IP4
PDB IDs		5NUG 5OWO 6F1T 6F1U 6F1V 6F1Y 6F38 6F3A 7Z8F 7Z8G 7Z8H 7Z8I 7Z8J 7Z8K 7Z8L 8DYU 8DYV 8FCY 8FD6 8FDT 8FDU 8PQV 8PQW 8PQY 8PQZ 8PR0 8PR1 8PR2 8PR3 8PTK	8EXE 8EXF
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction DNA Strand Resection Involved In Replication Fork Processing BRCA1-C Complex Cerebral Cortex Cell Migration Katanin Complex Radial Glia-guided Pyramidal Neuron Migration Telencephalon Cell Migration Signal Transduction Forebrain Cell Migration Microtubule Severing
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