DNAJA2 and DYRK3

Number of citations of the paper that reports this interaction (PubMedID 36585413)
42

Data Source:
BioGRID (two hybrid)

		DNAJA2	DYRK3
Description		DnaJ heat shock protein family (Hsp40) member A2	dual specificity tyrosine phosphorylation regulated kinase 3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Exosome	Pericentriolar Material Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Stress Granule Nuclear Speck
	Molecular Function	ATPase Activator Activity Protein Binding ATP Binding Zinc Ion Binding Hsp70 Protein Binding Heat Shock Protein Binding Metal Ion Binding Unfolded Protein Binding Protein-folding Chaperone Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Folding Positive Regulation Of Cell Population Proliferation Response To Heat Protein Refolding	Protein Phosphorylation Erythrocyte Differentiation Nuclear Speck Organization Stress Granule Disassembly Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Division Regulation Of Cellular Response To Stress Positive Regulation Of Cell Cycle G2/M Phase Transition Organelle Disassembly Regulation Of TORC1 Signaling
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Drugs
Diseases
GWAS		Factor VII activity ( 30642921)	Mean corpuscular volume ( 32888494)
Interacting Genes		10 interacting genes: DSCAM DYNLT1 DYRK3 ERG HSPA1A ITSN1 NEDD8 OGT PTEN UBC	12 interacting genes: ACAA2 ADAM22 DNAJA2 DNAJB1 FBXO25 GORASP2 MAGI2 NEDD4L PGM1 PRNP SNAPIN ZNF350
Entrez ID		10294	8444
HPRD ID		07105	04607
Ensembl ID		ENSG00000069345	ENSG00000143479
Uniprot IDs		O60884	O43781
PDB IDs		7ZHS	5Y86
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Protein Tag Activity Protein Modification Process Positive Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Social Behavior Ubiquitin Protein Ligase Binding Regulation Of Synapse Organization Regulation Of Cell Junction Assembly Negative Regulation Of Synaptic Vesicle Clustering Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Post-embryonic Retina Morphogenesis In Camera-type Eye Regulation Of Cellular Component Organization Netrin Receptor Binding Regulation Of Cell Development Regulation Of Neurogenesis Regulation Of Developmental Process Negative Regulation Of Protein Ubiquitination Denatured Protein Binding Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Clathrin-dependent Synaptic Vesicle Endocytosis Intracellular Transport Of Viral Protein In Host Cell Negative Regulation Of Post-translational Protein Modification Synapse Positive Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Phosphorus Metabolic Process Regulation Of Axonogenesis Nervous System Development Cell Projection Synapse Assembly Central Nervous System Development Regulation Of Nervous System Development Nucleoplasm Cytoplasm Protein Metabolic Process Cytosol Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Biological Process Involved In Interaction With Host C3HC4-type RING Finger Domain Binding Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Protein-folding Chaperone Binding
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