IRX5 and APLF

Number of citations of the paper that reports this interaction (PubMedID 17396150)
21

Data Source:
HPRD (in vitro)

		IRX5	APLF
Description		iroquois homeobox 5	aprataxin and PNKP like factor
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Site Of Double-strand Break Site Of DNA Damage
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Vitamin D Binding Identical Protein Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity DNA Endonuclease Activity Protein Binding Zinc Ion Binding 3'-5' Exonuclease Activity Hydrolase Activity Histone Binding Protein Folding Chaperone Metal Ion Binding Poly-ADP-D-ribose Binding Histone Chaperone Activity ADP-D-ribose Modification-dependent Protein Binding
	Biological Process	Regulation Of Heart Rate Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Visual Perception Gonad Development Regulation Of Gene Expression Neuron Differentiation Neuron Maturation Cell Development Embryonic Cranial Skeleton Morphogenesis Retinal Bipolar Neuron Differentiation	Single Strand Break Repair DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Protein Folding DNA Damage Response Embryo Implantation Regulation Of Epithelial To Mesenchymal Transition Regulation Of Isotype Switching Protein Localization To Chromatin DNA Repair-dependent Chromatin Remodeling
Pathways
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Brugada syndrome ( 35210625) Dialysis-related mortality ( 21546767) Heel bone mineral density ( 28869591 30598549) Hypospadias ( 25108383) Refractive error ( 32231278) Social communication problems ( 24564958) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)	Restless legs syndrome ( 29029846) Urate levels in lean individuals ( 25811787)
Interacting Genes		1 interacting genes: APLF	7 interacting genes: APP FBXO25 GMCL1 IRX5 LIG4 XRCC1 XRCC4
Entrez ID		10265	200558
HPRD ID		08395	09848
Ensembl ID		ENSG00000176842	ENSG00000169621
Uniprot IDs		P78411	Q8IW19
PDB IDs			2KQB 2KQC 2KQD 2KQE 2KUO 5E50 5W7W 5W7X 5W7Y 6ERF 6TYT 6TYW 6TYZ 6YN1
Enriched GO Terms of Interacting Partners?		Histone Chaperone Activity ADP-D-ribose Modification-dependent Protein Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Poly-ADP-D-ribose Binding Single Strand Break Repair 3'-5' Exonuclease Activity DNA Endonuclease Activity DNA Repair-dependent Chromatin Remodeling Regulation Of Isotype Switching Embryo Implantation Site Of DNA Damage Protein Localization To Chromatin Protein Folding Chaperone Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Immunoglobulin Production Site Of Double-strand Break Protein Localization To Chromosome Regulation Of Epithelial To Mesenchymal Transition Regulation Of B Cell Activation Regulation Of DNA Recombination Histone Binding Protein Folding Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Lymphocyte Mediated Immunity Double-strand Break Repair Regulation Of Adaptive Immune Response	Base-excision Repair DNA Ligase IV Complex Double-strand Break Repair Via Nonhomologous End Joining DNA-dependent Protein Kinase-DNA Ligase 4 Complex Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Single Strand Break Repair Cellular Response To Lithium Ion Response To Lithium Ion V(D)J Recombination Cellular Response To Metal Ion Response To X-ray Neuron Maturation Somatic Recombination Of Immunoglobulin Gene Segments Condensed Chromosome Double-strand Break Repair DNA Recombination Somatic Cell DNA Recombination Somatic Diversification Of Immunoglobulins Response To Metal Ion Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Establishment Of Integrated Proviral Latency Oxidized DNA Binding FHA Domain Binding Response To Radiation Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Establishment Of Viral Latency Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Nucleus Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization DNA Ligase (ATP) Activity DNA Repair Ligase Activity DNA Ligase Activity
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