IRX5

Description		iroquois homeobox 5
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Vitamin D Binding Identical Protein Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Heart Rate Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Visual Perception Gonad Development Regulation Of Gene Expression Neuron Differentiation Neuron Maturation Cell Development Embryonic Cranial Skeleton Morphogenesis Retinal Bipolar Neuron Differentiation
Pathways
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Brugada syndrome ( 35210625) Dialysis-related mortality ( 21546767) Heel bone mineral density ( 28869591 30598549) Hypospadias ( 25108383) Refractive error ( 32231278) Social communication problems ( 24564958) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Novel Interacting Genes		1 novel interacting genes: APLF
Interacting Genes		1 interacting genes: APLF
Entrez ID		10265
HPRD ID		08395
Ensembl ID		ENSG00000176842
Uniprot IDs		P78411
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone Chaperone Activity ADP-D-ribose Modification-dependent Protein Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Poly-ADP-D-ribose Binding Single Strand Break Repair 3'-5' Exonuclease Activity DNA Endonuclease Activity DNA Repair-dependent Chromatin Remodeling Regulation Of Isotype Switching Embryo Implantation Site Of DNA Damage Protein Localization To Chromatin Protein Folding Chaperone Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Immunoglobulin Production Site Of Double-strand Break Protein Localization To Chromosome Regulation Of Epithelial To Mesenchymal Transition Regulation Of B Cell Activation Regulation Of DNA Recombination Histone Binding Protein Folding Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Lymphocyte Mediated Immunity Double-strand Break Repair Regulation Of Adaptive Immune Response
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