TRIM13 and UBE2H

Number of citations of the paper that reports this interaction (PubMedID 37205848)
54

Data Source:
BioGRID (pull down)

		TRIM13	UBE2H
Description		tripartite motif containing 13	ubiquitin conjugating enzyme E2 H
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Quality Control Compartment Perinuclear Endoplasmic Reticulum	Nucleus Cytosol
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-like Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Immune System Process Positive Regulation Of Macroautophagy Protein Ubiquitination Negative Regulation Of Viral Transcription ERAD Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein Autoubiquitination Endoplasmic Reticulum Mannose Trimming	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		ER Quality Control Compartment (ERQC)	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Etorphine Diprenorphine Dihydromorphine
Diseases
GWAS		Diastolic blood pressure ( 30224653) Height ( 23563607) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)
Interacting Genes		16 interacting genes: AKT1 ARHGDIA CCNA1 CDC34 GMCL1 MDM2 ROBO2 UBE2C UBE2D2 UBE2D3 UBE2E1 UBE2H UBE2K UBE2L3 UBE2L6 UBE2N	71 interacting genes: BRAP CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GID4 GOLGA2 H2AC18 H2AC20 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MDM2 MKRN3 NEURL1 NEURL2 NHLRC1 POLL POLM PRKN PSME3 RAG1 RBX1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 STUB1 TLE5 TRAIP TRIM13 TRIM17 TRIM2 TRIM23 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBASH3B UBOX5 UBR2 UBR3
Entrez ID		10206	7328
HPRD ID		10414	03052
Ensembl ID		ENSG00000204977	ENSG00000186591
Uniprot IDs		O60858	A0A3B3IU20 A4D1L5 P62256
PDB IDs			2Z5D 8PJN
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Macromolecule Catabolic Process Protein K48-linked Ubiquitination Proteolysis Protein K11-linked Ubiquitination Protein Modification Process Transferase Activity Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process ATP Binding Proteasomal Protein Catabolic Process Nucleotide Binding Protein Metabolic Process Protein Catabolic Process Ubiquitin-like Protein Transferase Activity Ubiquitin Ligase Complex Nucleus ISG15 Transferase Activity Cytosol ISG15-protein Conjugation Cell Cycle Phase Transition Free Ubiquitin Chain Polymerization Protein Monoubiquitination Positive Regulation Of Protein Modification Process Regulation Of Protein Ubiquitination Ubiquitin-protein Transferase Activator Activity Protein Autoubiquitination Positive Regulation Of Protein Metabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Mitotic Cell Cycle Phase Transition Ubiquitin Binding Nucleoplasm Positive Regulation Of Protein Ubiquitination Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Cycle Phase Transition Response To Ether Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Cell Cycle Cellular Response To Hormone Stimulus Regulation Of Protein Modification Process Negative Regulation Of Protein Maturation	Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Transferase Activity Protein Modification Process Zinc Ion Binding Protein Metabolic Process Protein Polyubiquitination Metal Ion Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Macromolecule Metabolic Process Macromolecule Catabolic Process Proteolysis Protein Catabolic Process Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Protein Monoubiquitination Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination Autophagy Positive Regulation Of Catabolic Process Cytoplasm Endoplasmic Reticulum Mannose Trimming Protein K48-linked Ubiquitination Regulation Of Protein Catabolic Process Protein Alpha-1,2-demannosylation Suppression Of Viral Release By Host Immune System Process Protein Deglycosylation Aggresome Assembly Innate Immune Response Positive Regulation Of Protein Catabolic Process ERAD Pathway Endoplasmic Reticulum Quality Control Compartment Cellular Response To Stress Protein K6-linked Ubiquitination Ubiquitin Binding Inclusion Body Assembly Response To Endoplasmic Reticulum Stress Positive Regulation Of Autophagy Aggresome Defense Response To Symbiont Defense Response To Other Organism
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