UBE2H and TRIM56

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		UBE2H	TRIM56
Description		ubiquitin conjugating enzyme E2 H	tripartite motif containing 56
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GO Annotations	Cellular Component	Nucleus Cytosol	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Immune System Process Protein Monoubiquitination Protein Ubiquitination Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Response To Type I Interferon Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Protein K63-linked Ubiquitination CGAS/STING Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Regulation of innate immune responses to cytosolic DNA
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)	Alzheimer's disease ( 30636644) Nonunion in individuals with fractures ( 30680360)
Interacting Genes		71 interacting genes: BRAP CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GID4 GOLGA2 H2AC18 H2AC20 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MDM2 MKRN3 NEURL1 NEURL2 NHLRC1 POLL POLM PRKN PSME3 RAG1 RBX1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 STUB1 TLE5 TRAIP TRIM13 TRIM17 TRIM2 TRIM23 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBASH3B UBOX5 UBR2 UBR3	5 interacting genes: MIR200C MIR25 MIR34B UBE2H WEE2-AS1
Entrez ID		7328	81844
HPRD ID		03052	10284
Ensembl ID		ENSG00000186591	ENSG00000169871
Uniprot IDs		A0A3B3IU20 A4D1L5 P62256	Q9BRZ2
PDB IDs		2Z5D 8PJN	5JW7
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Transferase Activity Protein Modification Process Zinc Ion Binding Protein Metabolic Process Protein Polyubiquitination Metal Ion Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Macromolecule Metabolic Process Macromolecule Catabolic Process Proteolysis Protein Catabolic Process Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Protein Monoubiquitination Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination Autophagy Positive Regulation Of Catabolic Process Cytoplasm Endoplasmic Reticulum Mannose Trimming Protein K48-linked Ubiquitination Regulation Of Protein Catabolic Process Protein Alpha-1,2-demannosylation Suppression Of Viral Release By Host Immune System Process Protein Deglycosylation Aggresome Assembly Innate Immune Response Positive Regulation Of Protein Catabolic Process ERAD Pathway Endoplasmic Reticulum Quality Control Compartment Cellular Response To Stress Protein K6-linked Ubiquitination Ubiquitin Binding Inclusion Body Assembly Response To Endoplasmic Reticulum Stress Positive Regulation Of Autophagy Aggresome Defense Response To Symbiont Defense Response To Other Organism	MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Muscle System Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Cardiac Muscle Hypertrophy RISC Complex MRNA Destabilization RNA Destabilization Regulation Of System Process Post-transcriptional Regulation Of Gene Expression Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Transmembrane Transport MRNA 3'-UTR Binding Negative Regulation Of Interleukin-33 Production Positive Regulation Of MRNA Metabolic Process Positive Regulation Of Mesodermal Cell Differentiation Pre-mRNA 5'-splice Site Binding Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Negative Regulation Of Response To Drug Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Calcium Ion Import Across Plasma Membrane MRNA 5'-splice Site Recognition Regulation Of Response To Drug Regulation Of Mesodermal Cell Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of MRNA Metabolic Process Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Endothelial Cell Differentiation Regulation Of Connective Tissue Replacement Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Multicellular Organismal Development U1 SnRNP Negative Regulation Of Transport Positive Regulation Of Tissue Remodeling Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Cardiac Muscle Tissue Growth Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Ubiquitin Conjugating Enzyme Activity MRNA Splice Site Recognition
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