CALCRL and ADM

Number of citations of the paper that reports this interaction (PubMedID 9620797)
0

Data Source:
HPRD (in vitro, in vivo)

		CALCRL	ADM
Description		calcitonin receptor like receptor	adrenomedullin
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Endoplasmic Reticulum Plasma Membrane Membrane Adrenomedullin Receptor Complex CGRP Receptor Complex	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Lumen
	Molecular Function	Adrenomedullin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcitonin Receptor Activity Protein Binding Adrenomedullin Binding	Signaling Receptor Binding Hormone Activity Adrenomedullin Receptor Binding Receptor Ligand Activity
	Biological Process	Angiogenesis Calcium Ion Transport Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Protein Transport Receptor Internalization Smooth Muscle Cell Proliferation Cellular Response To Sucrose Stimulus Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Calcitonin Gene-related Peptide Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway Vascular Associated Smooth Muscle Cell Proliferation	Vasculogenesis Neural Tube Closure Response To Yeast G Protein-coupled Receptor Internalization Regulation Of Systemic Arterial Blood Pressure Inflammatory Response Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Antibacterial Humoral Response Antifungal Humoral Response Receptor Internalization Regulation Of Urine Volume Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Negative Regulation Of Vasoconstriction Developmental Growth Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Branching Involved In Labyrinthine Layer Morphogenesis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Vascular Associated Smooth Muscle Cell Development Calcitonin Family Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway Positive Regulation Of Progesterone Biosynthetic Process Positive Regulation Of Vasculogenesis
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	G alpha (s) signalling events Calcitonin-like ligand receptors High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Olcegepant Telcagepant Rimegepant Erenumab Ubrogepant Zavegepant Atogepant
Diseases
GWAS		A body shape index ( 34021172) Aspartate aminotransferase levels ( 33547301) Body mass index ( 25673413) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Periventricular white matter hyperintensities ( 32517579) Resting heart rate ( 27798624) Serum immune biomarker levels ( 32066700) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412) White blood cell count ( 32888494) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Birth weight ( 31043758) Blood pressure ( 21909110) Blood protein levels in cardiovascular risk ( 28369058) Circulating vasoactive peptide levels ( 23381795) Diastolic blood pressure ( 21909115 27618452 27841878) HDL cholesterol ( 20686565) Neuroticism ( 27089181) Pulse pressure ( 27841878) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Systolic blood pressure ( 21909115 27618452 27841878) Total cholesterol levels ( 33339817)
Interacting Genes		6 interacting genes: ADM CALCA CRCP RAMP1 RAMP2 RAMP3	6 interacting genes: CALCRL CFH DCLK3 EDN1 MME SNCA
Entrez ID		10203	133
HPRD ID		11809	00061
Ensembl ID		ENSG00000064989	ENSG00000148926
Uniprot IDs		Q16602	P35318
PDB IDs		3AQF 3N7P 3N7R 3N7S 4RWF 4RWG 5V6Y 6D1U 6E3Y 6UMG 6UUN 6UUS 6UVA 6V2E 6ZHO 6ZIS 7KNT 7KNU 7P0F 7P0I 8AX5 8AX6 8AX7	2FLY 2L7S 4RWF 5V6Y 6UUN 6UUS 6V2E 7VV0
Enriched GO Terms of Interacting Partners?		Calcitonin Family Receptor Signaling Pathway Amylin Receptor Signaling Pathway Receptor Internalization Adrenomedullin Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Endocytosis Adrenomedullin Receptor Activity Adrenomedullin Receptor Complex Amylin Receptor Activity Import Into Cell Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Calcitonin Gene-related Peptide Receptor Activity Coreceptor Activity Calcitonin Gene-related Peptide Receptor Signaling Pathway Antifungal Humoral Response Vascular Associated Smooth Muscle Cell Development Positive Regulation Of Vasculogenesis Vesicle-mediated Transport G Protein-coupled Receptor Internalization Response To Yeast Regulation Of Vasculogenesis Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Regulation Of Blood Pressure Protein Localization To Plasma Membrane Receptor Complex Protein Localization To Cell Periphery Calcium Ion Transport Vascular Process In Circulatory System Regulation Of Vascular Permeability Protein Localization To Membrane Circulatory System Process Defense Response To Fungus Cellular Response To Hormone Stimulus Response To Fungus Antibacterial Humoral Response Vasculogenesis Signal Transduction Adrenomedullin Receptor Binding Positive Regulation Of Progesterone Biosynthetic Process Calcitonin Gene-related Peptide Binding Cross-receptor Inhibition Within G Protein-coupled Receptor Heterodimer DNA Polymerase III Complex Defense Response To Gram-negative Bacterium Positive Regulation Of Biosynthetic Process Muscle Cell Development	Response To Interleukin-1 Negative Regulation Of Phospholipase C/protein Kinase C Signal Transduction Endothelin B Receptor Binding Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Endothelin A Receptor Binding Response To Prostaglandin F Modulation Of Chemical Synaptic Transmission Regulation Of Ketone Metabolic Process Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Response To Peptide Cellular Response To Human Chorionic Gonadotropin Stimulus Response To Cytokine Rough Endoplasmic Reticulum Lumen Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Rhythmic Excitation Rhythmic Synaptic Transmission Response To Type II Interferon Endothelin Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Chemokine-mediated Signaling Pathway Regulation Of Fatty Acid Metabolic Process Synaptic Vesicle Oligopeptidase Activity Substance P Catabolic Process Positive Regulation Of Synaptic Transmission Creatinine Metabolic Process Neuropeptide Processing Response To Desipramine Negative Regulation Of Serotonin Uptake Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Transporter Regulator Activity Regulation Of Norepinephrine Uptake Positive Regulation Of SNARE Complex Assembly Receptor Internalization Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Chaperone-mediated Autophagy Adrenomedullin Binding CGRP Receptor Complex Adrenomedullin Receptor Complex Adrenomedullin Receptor Activity Calcitonin Receptor Activity Cellular Response To Sucrose Stimulus Maternal Process Involved In Parturition Vein Smooth Muscle Contraction
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