CALCRL

Description		calcitonin receptor like receptor
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GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Endoplasmic Reticulum Plasma Membrane Membrane Adrenomedullin Receptor Complex CGRP Receptor Complex
	Molecular Function	Adrenomedullin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcitonin Receptor Activity Protein Binding Adrenomedullin Binding
	Biological Process	Angiogenesis Calcium Ion Transport Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Protein Transport Receptor Internalization Smooth Muscle Cell Proliferation Cellular Response To Sucrose Stimulus Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Calcitonin Gene-related Peptide Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway Vascular Associated Smooth Muscle Cell Proliferation
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Olcegepant Telcagepant Rimegepant Erenumab Ubrogepant Zavegepant Atogepant
Diseases
GWAS		A body shape index ( 34021172) Aspartate aminotransferase levels ( 33547301) Body mass index ( 25673413) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Periventricular white matter hyperintensities ( 32517579) Resting heart rate ( 27798624) Serum immune biomarker levels ( 32066700) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412) White blood cell count ( 32888494) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Novel Interacting Genes		6 novel interacting genes: ADM CALCA CRCP RAMP1 RAMP2 RAMP3
Interacting Genes		6 interacting genes: ADM CALCA CRCP RAMP1 RAMP2 RAMP3
Entrez ID		10203
HPRD ID		11809
Ensembl ID		ENSG00000064989
Uniprot IDs		Q16602
PDB IDs		3AQF 3N7P 3N7R 3N7S 4RWF 4RWG 5V6Y 6D1U 6E3Y 6UMG 6UUN 6UUS 6UVA 6V2E 6ZHO 6ZIS 7KNT 7KNU 7P0F 7P0I 8AX5 8AX6 8AX7
Enriched GO Terms of Interacting Partners?		Calcitonin Family Receptor Signaling Pathway Amylin Receptor Signaling Pathway Receptor Internalization Adrenomedullin Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Endocytosis Adrenomedullin Receptor Activity Adrenomedullin Receptor Complex Amylin Receptor Activity Import Into Cell Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Calcitonin Gene-related Peptide Receptor Activity Coreceptor Activity Calcitonin Gene-related Peptide Receptor Signaling Pathway Antifungal Humoral Response Vascular Associated Smooth Muscle Cell Development Positive Regulation Of Vasculogenesis Vesicle-mediated Transport G Protein-coupled Receptor Internalization Response To Yeast Regulation Of Vasculogenesis Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Regulation Of Blood Pressure Protein Localization To Plasma Membrane Receptor Complex Protein Localization To Cell Periphery Calcium Ion Transport Vascular Process In Circulatory System Regulation Of Vascular Permeability Protein Localization To Membrane Circulatory System Process Defense Response To Fungus Cellular Response To Hormone Stimulus Response To Fungus Antibacterial Humoral Response Vasculogenesis Signal Transduction Adrenomedullin Receptor Binding Positive Regulation Of Progesterone Biosynthetic Process Calcitonin Gene-related Peptide Binding Cross-receptor Inhibition Within G Protein-coupled Receptor Heterodimer DNA Polymerase III Complex Defense Response To Gram-negative Bacterium Positive Regulation Of Biosynthetic Process Muscle Cell Development
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