FARP1 and PIH1D1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FARP1	PIH1D1
Description		FERM, ARH/RhoGEF and pleckstrin domain protein 1	PIH1 domain containing 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Filopodium Dendrite Cell Projection Neuron Projection Dendritic Spine Synapse Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse	Nucleus Nucleolus Cytoplasm Pre-snoRNP Complex R2TP Complex RPAP3/R2TP/prefoldin-like Complex Ribonucleoprotein Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Cytoskeletal Protein Binding Small GTPase Binding	RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Protein Kinase Binding Histone Binding ATPase Binding Phosphoprotein Binding Histone Reader Activity
	Biological Process	Enzyme-linked Receptor Protein Signaling Pathway Synapse Assembly Rac Protein Signal Transduction Dendrite Morphogenesis Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Presynapse Assembly	Box C/D SnoRNP Assembly Chromatin Remodeling RRNA Processing Epithelial Cell Differentiation SnoRNA Localization Protein Stabilization Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of TORC2 Signaling Positive Regulation Of TORC1 Signaling TORC1 Complex Assembly
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Bell's palsy ( 33602968) Brain structure ( 20171287) Clozapine-induced agranulocytosis ( 25187353) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 33020668) Educational attainment ( 25201988) Gastroesophageal reflux disease ( 34187846) General factor of neuroticism ( 30867560) Heel bone mineral density x serum urate levels interaction ( 34046847) Household income ( 31844048) Household income (MTAG) ( 31844048) LDL cholesterol levels in HIV infection ( 33109212) Mood instability ( 31168069) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Obesity-related traits ( 23251661) Pelvic organ prolapse ( 26545240) Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction ( 31092817) Response to amphetamines ( 22952603) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		1 interacting genes: PIH1D1	19 interacting genes: BYSL CA4 CDCA7L EAF1 FAM90A1 FARP1 GEM MAPK6 MFAP1 MISP PLEKHN1 RBPMS RCOR3 SCNM1 SEPTIN1 SMARCD1 TNS4 TSC22D4 UBC
Entrez ID		10160	55011
HPRD ID		16006	07938
Ensembl ID		ENSG00000152767	ENSG00000104872
Uniprot IDs		A0A2X0TVY0 C9JME2 Q9Y4F1	Q9NWS0
PDB IDs		4H6Y	4PSF 4PSI 6GXZ 7AVC 8BDU
Enriched GO Terms of Interacting Partners?		RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding SnoRNA Localization Positive Regulation Of Glucose Mediated Signaling Pathway TORC1 Complex Assembly R2TP Complex Regulation Of Glucose Mediated Signaling Pathway Pre-snoRNP Complex Regulation Of TORC2 Signaling Box C/D SnoRNP Assembly RPAP3/R2TP/prefoldin-like Complex Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Histone Reader Activity RNA Localization Positive Regulation Of Transcription By RNA Polymerase I Phosphoprotein Binding Regulation Of Transcription By RNA Polymerase I Positive Regulation Of TORC1 Signaling ATPase Binding Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Regulation Of TOR Signaling Histone Binding RRNA Processing Protein-RNA Complex Assembly Protein Stabilization RRNA Metabolic Process
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