FARP1

Description		FERM, ARH/RhoGEF and pleckstrin domain protein 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Filopodium Dendrite Cell Projection Neuron Projection Dendritic Spine Synapse Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Cytoskeletal Protein Binding Small GTPase Binding
	Biological Process	Enzyme-linked Receptor Protein Signaling Pathway Synapse Assembly Rac Protein Signal Transduction Dendrite Morphogenesis Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Presynapse Assembly
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Bell's palsy ( 33602968) Brain structure ( 20171287) Clozapine-induced agranulocytosis ( 25187353) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 33020668) Educational attainment ( 25201988) Gastroesophageal reflux disease ( 34187846) General factor of neuroticism ( 30867560) Heel bone mineral density x serum urate levels interaction ( 34046847) Household income ( 31844048) Household income (MTAG) ( 31844048) LDL cholesterol levels in HIV infection ( 33109212) Mood instability ( 31168069) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Obesity-related traits ( 23251661) Pelvic organ prolapse ( 26545240) Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction ( 31092817) Response to amphetamines ( 22952603) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
Novel Interacting Genes		1 novel interacting genes: PIH1D1
Interacting Genes		1 interacting genes: PIH1D1
Entrez ID		10160
HPRD ID		16006
Ensembl ID		ENSG00000152767
Uniprot IDs		A0A2X0TVY0 C9JME2 Q9Y4F1
PDB IDs		4H6Y
Enriched GO Terms of Interacting Partners?		RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding SnoRNA Localization Positive Regulation Of Glucose Mediated Signaling Pathway TORC1 Complex Assembly R2TP Complex Regulation Of Glucose Mediated Signaling Pathway Pre-snoRNP Complex Regulation Of TORC2 Signaling Box C/D SnoRNP Assembly RPAP3/R2TP/prefoldin-like Complex Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Histone Reader Activity RNA Localization Positive Regulation Of Transcription By RNA Polymerase I Phosphoprotein Binding Regulation Of Transcription By RNA Polymerase I Positive Regulation Of TORC1 Signaling ATPase Binding Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Regulation Of TOR Signaling Histone Binding RRNA Processing Protein-RNA Complex Assembly Protein Stabilization RRNA Metabolic Process
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