EBI3 and IL12A

Number of citations of the paper that reports this interaction (PubMedID 934235)
0

Data Source:
HPRD (in vivo)

		EBI3	IL12A
Description		Epstein-Barr virus induced 3	interleukin 12A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Late Endosome Lumen Interleukin-12 Complex
	Molecular Function	Cytokine Receptor Activity Cytokine Activity Protein Binding Interleukin-27 Receptor Binding	Cytokine Activity Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Interleukin-12 Beta Subunit Binding Interleukin-27 Binding Protein Heterodimerization Activity
	Biological Process	Immune System Process Humoral Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Type II Interferon Production T-helper 1 Type Immune Response T Cell Proliferation Positive Regulation Of Alpha-beta T Cell Proliferation	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response Response To Virus Response To UV-B Cell Migration Response To Lipopolysaccharide Negative Regulation Of Interleukin-17 Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Interleukin-12-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein T-helper 1 Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Negative Regulation Of Protein Secretion Defense Response To Gram-positive Bacterium Positive Regulation Of NK T Cell Activation Extrinsic Apoptotic Signaling Pathway Cellular Response To Virus Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Dendritic Cell Chemotaxis
Pathways		Interleukin-35 Signalling Interleukin-27 signaling	Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Triglyceride levels ( 32154731)	Autoimmune traits (pleiotropy) ( 30572963) Behcet's disease ( 25799145 27548383 23291587) Bipolar disorder ( 31043756) Celiac disease ( 18311140 25920553 22057235 20190752) Limited cutaneous systemic scleroderma ( 24387989) Major depressive disorder ( 23377640) Multiple sclerosis ( 21833088 24076602 19525953) Primary biliary cholangitis ( 28425483 28062665 19458352 26394269 21399635 20639880) Primary biliary cirrhosis ( 22961000) Sjögren's syndrome ( 24097067) Systemic lupus erythematosus ( 26502338 27399966 28714469) Systemic sclerosis ( 24387989 31672989)
Interacting Genes		9 interacting genes: CANX GOSR1 IL12A IL27RA MDFI S100A6 S100P SMAD3 UBC	7 interacting genes: CD28 CXCL8 EBI3 IL12B S100A6 S100P WASF1
Entrez ID		10148	3592
HPRD ID		12051	01193
Ensembl ID		ENSG00000105246	ENSG00000168811
Uniprot IDs		Q14213	O60595 P29459
PDB IDs		7U7N 7ZXK 8D85 8XWY	1F45 3HMX 8XRP 8YI7
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Interleukin-17 Production	Positive Regulation Of Alpha-beta T Cell Proliferation T Cell Proliferation Positive Regulation Of Alpha-beta T Cell Activation T-helper 1 Type Immune Response Positive Regulation Of T Cell Proliferation Lymphocyte Proliferation Regulation Of Alpha-beta T Cell Activation Mononuclear Cell Proliferation Leukocyte Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Leukocyte Proliferation Leukocyte Activation Regulation Of T Cell Proliferation Cell Activation Cytokine Activity Positive Regulation Of Interleukin-10 Production Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Humoral Immune Response Regulation Of Cell Population Proliferation Regulation Of Leukocyte Proliferation Regulation Of Mononuclear Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Cytokine Receptor Activity T Cell Activation Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Population Proliferation CD4-positive, Alpha-beta T Cell Activation Regulation Of Interleukin-10 Production Positive Regulation Of Immune System Process Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Type II Interferon Production Interleukin-12 Alpha Subunit Binding Regulation Of Viral Genome Replication Calcium-dependent Protein Binding Extracellular Region Regulation Of CD4-positive, Alpha-beta T Cell Activation Lymphocyte Activation Immune Response Positive Regulation Of Cell Adhesion Alpha-beta T Cell Activation Positive Regulation Of Gene Expression Regulation Of Cell-cell Adhesion Interleukin-8 Receptor Binding Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains
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