TOB1 and MAPK9

Number of citations of the paper that reports this interaction (PubMedID 12151396)
0

Data Source:
BioGRID (pull down, enzymatic study)

		TOB1	MAPK9
Description		transducer of ERBB2, 1	mitogen-activated protein kinase 9
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm CCR4-NOT Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Nuclear Speck Schaffer Collateral - CA1 Synapse
	Molecular Function	Transcription Corepressor Activity Protein Binding Receptor Tyrosine Kinase Binding SMAD Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	MAPK Cascade Protein Phosphorylation JNK Cascade Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Reactive Oxygen Species Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Regulation Of MRNA Stability Response To Cadmium Ion Rhythmic Process Modulation Of Chemical Synaptic Transmission MRNA Destabilization Protein Localization To Tricellular Tight Junction Positive Regulation Of Podosome Assembly Cellular Senescence Inflammatory Response To Wounding Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Apoptotic Signaling Pathway
Pathways			Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors Signaling by ALK fusions and activated point mutants
Drugs			Minocycline N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide Fostamatinib Halicin
Diseases
GWAS			Appendicular lean mass ( 33097823) Blood protein levels ( 30072576)
Interacting Genes		20 interacting genes: APP CDC7 CNOT7 CORO7 DTL ERBB2 IKZF3 MAPK1 MAPK9 MARCKS PABPC1 SCMH1 SETDB1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMAD9	112 interacting genes: ACP5 AKT1 ARRB1 ARRB2 ATF2 ATF7 BCL2L1 BCL2L11 BTRC C1orf105 C1orf94 CASP3 CBLL2 CCDC33 CDC16 CDC25B CDC25C CEP126 CEP44 CLU CTBP1 CTNNB1 DCX DTX3 DUSP10 DUSP16 DUSP19 DUSP4 EEF2K EFHC2 EGFR ELK1 ELK3 ENKD1 FBXO7 GFAP GOLGA6A GRB2 GSC2 H3-3A HDAC9 HSF1 IHO1 IRS1 ITGB3BP JDP2 JUN JUNB JUND KLHL8 KPNA3 L3MBTL3 LHX3 LMAN2 LNX1 LNX2 LZTS1 MACF1 MAP2K4 MAP2K7 MAP3K1 MAP3K10 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAPK5 MAPKBP1 MAPT MCRS1 MED12L MEOX1 MLIP NCF1 NCSTN NFATC3 NFATC4 NHSL2 PAX5 PBX4 PICK1 POU6F2 PPARG PRKD1 PSEN1 RB1 RPS6KB1 RSPO4 SAXO1 SDCBP SF3B4 SH3BP5 SHMT1 SLIT3 SMAD2 SMAD3 SMCO3 SSU72 TCP10L TEX11 TOB1 TP53 TRAF2 TUSC2 WDR62 XPNPEP1 XPO7 ZBTB25 ZC2HC1C ZFTRAF1 ZNF138 ZNF559 ZNHIT1
Entrez ID		10140	5601
HPRD ID		09273	04206
Ensembl ID		ENSG00000141232	ENSG00000050748
Uniprot IDs		P50616	D7R525 P45984
PDB IDs		2D5R 2Z15 5CI8 5CI9	3E7O 3NPC 7CML 7N8T 8ELC
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Complex SMAD Protein Signal Transduction Response To Growth Factor Embryonic Pattern Specification Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signaling Cassette Cellular Response To Growth Factor Stimulus Co-SMAD Binding Ureteric Bud Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Macromolecule Metabolic Process Tube Development Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Positive Regulation Of Metabolic Process Kidney Epithelium Development Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MiRNA Transcription R-SMAD Binding BMP Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Metabolic Process Positive Regulation Of Biosynthetic Process DEAD/H-box RNA Helicase Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Epithelium Development Regulation Of Primary Metabolic Process Regulation Of Cell Differentiation Osteoblast Differentiation Primary MiRNA Processing Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cytoplasm Positive Regulation Of MiRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Binding Tissue Development Cardiac Conduction System Development Positive Regulation Of MiRNA Metabolic Process Cytosol	Intracellular Signaling Cassette Intracellular Signal Transduction MAPK Cascade Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Protein Kinase Binding Cellular Developmental Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway Nucleus Positive Regulation Of Transcription By RNA Polymerase II JNK Cascade JUN Kinase Binding Programmed Cell Death Cell Death Negative Regulation Of Apoptotic Process Cytoplasm Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Protein Binding Negative Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process
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