TOB1 and SMAD6

Number of citations of the paper that reports this interaction (PubMedID 12782279)
0

Data Source:
HPRD (two hybrid)

		TOB1	SMAD6
Description		transducer of ERBB2, 1	SMAD family member 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm CCR4-NOT Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Golgi Apparatus Cytosol Cilium Nuclear Body Protein-containing Complex Ciliary Basal Body Heteromeric SMAD Protein Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Receptor Tyrosine Kinase Binding SMAD Binding	Transcription Cis-regulatory Region Binding Chromatin Binding Protein Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Activin Receptor Binding Type I Activin Receptor Binding Protein Sequestering Activity Transcription Regulator Inhibitor Activity
	Biological Process	Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Ureteric Bud Development Outflow Tract Septum Morphogenesis Heart Valve Development Aortic Valve Morphogenesis Mitral Valve Morphogenesis Pulmonary Valve Morphogenesis Ventricular Septum Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Immune Response Zygotic Specification Of Dorsal/ventral Axis Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Cell Differentiation Negative Regulation Of Ossification BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Cell-substrate Adhesion Response To Lipopolysaccharide Negative Regulation Of Activin Receptor Signaling Pathway Response To Laminar Fluid Shear Stress Aorta Development Negative Regulation Of Apoptotic Process Response To Estrogen Fat Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Coronary Vasculature Development Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of MiRNA Transcription
Pathways			Signaling by BMP RUNX2 regulates bone development
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Asthma ( 29273806 31959851) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Carpal tunnel syndrome ( 30833571) Dental caries (decayed and filled deciduous teeth) ( 31533690) Glaucoma (primary open-angle) ( 33627673) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Lung cancer (smoking interaction) ( 24658283) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Refractive error ( 32231278) Severe aortic features in Marfan syndrome ( 30087447) Subcutaneous adipose tissue ( 22589738) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		20 interacting genes: APP CDC7 CNOT7 CORO7 DTL ERBB2 IKZF3 MAPK1 MAPK9 MARCKS PABPC1 SCMH1 SETDB1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMAD9	24 interacting genes: ANXA2 BMPR1B CHRM5 HOXC8 MAP3K7 MAPK6 MYO1E PIGB PIK3R4 PPIB RAB11A RNF111 RPS6KA5 RUNX2 SMAD1 SMAD7 SMURF1 SMURF2 STAMBP STRAP TAB1 TGFBR1 TOB1 UACA
Entrez ID		10140	4091
HPRD ID		09273	04240
Ensembl ID		ENSG00000141232	ENSG00000137834
Uniprot IDs		P50616	O43541
PDB IDs		2D5R 2Z15 5CI8 5CI9
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Complex SMAD Protein Signal Transduction Response To Growth Factor Embryonic Pattern Specification Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signaling Cassette Cellular Response To Growth Factor Stimulus Co-SMAD Binding Ureteric Bud Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Macromolecule Metabolic Process Tube Development Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Positive Regulation Of Metabolic Process Kidney Epithelium Development Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MiRNA Transcription R-SMAD Binding BMP Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Metabolic Process Positive Regulation Of Biosynthetic Process DEAD/H-box RNA Helicase Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Epithelium Development Regulation Of Primary Metabolic Process Regulation Of Cell Differentiation Osteoblast Differentiation Primary MiRNA Processing Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cytoplasm Positive Regulation Of MiRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Binding Tissue Development Cardiac Conduction System Development Positive Regulation Of MiRNA Metabolic Process Cytosol	Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway SMAD Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway I-SMAD Binding Regulation Of Cartilage Development Positive Regulation Of Cartilage Development Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Chondrocyte Differentiation Negative Regulation Of BMP Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process BMP Signaling Pathway SMAD Protein Signal Transduction Osteoblast Fate Commitment Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Signal Transduction Negative Regulation Of Chondrocyte Proliferation Transforming Growth Factor Beta Receptor Activity, Type I Regulation Of BMP Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Activin Receptor Binding Cellular Response To Growth Factor Stimulus Regulation Of Multicellular Organismal Process Regulation Of Cell Communication Positive Regulation Of Developmental Process Regulation Of Osteoblast Differentiation Protein Kinase Activity Transferase Activity Heteromeric SMAD Protein Complex Positive Regulation Of CGAS/STING Signaling Pathway Regulation Of Signal Transduction Protein-containing Complex Regulation Of Metabolic Process Response To Growth Factor Intracellular Signal Transduction Type II Transforming Growth Factor Beta Receptor Binding Regulation Of Macromolecule Metabolic Process Protein Phosphorylation Regulation Of Primary Metabolic Process
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