HMGXB4 and DNAL4

		HMGXB4	DNAL4
Description		HMG-box containing 4	dynein axonemal light chain 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus NURF Complex	Cytoplasm Cytoskeleton Microtubule Plasma Membrane Cilium Dynein Complex Cell Projection
	Molecular Function	DNA Binding Protein Binding Identical Protein Binding	Microtubule Motor Activity Protein Binding Identical Protein Binding
	Biological Process	Endosome To Lysosome Transport Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway	Microtubule-based Process Microtubule-based Movement
Pathways			Retrograde neurotrophin signalling
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) Platelet count ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		27 interacting genes: AKAP17A CACNA1I CREBBP DNAL4 EPM2A H3-4 HABP4 INO80B JMJD6 LENG8 MX1 NKAPD1 NR1H2 PIAS2 SRPK2 STAC3 STRBP SUMO2 TAB1 TENT5B TNNT1 TSC22D1 TSPYL2 UBE2I UBL5 UROD ZCCHC10	23 interacting genes: CACNA1I CHIC2 DDX17 DYNLL2 FHL5 GNA14 GPBP1 GTPBP1 HMGXB4 JOSD1 KRTAP10-3 KRTAP12-3 KRTAP9-8 NFATC2IP NOTCH2NLA NTAQ1 NUDT22 RHOT2 SCTR TOM1 TRIM54 TRIOBP UBA7
Entrez ID		10042	10126
HPRD ID		05267	13239
Ensembl ID		ENSG00000100281	ENSG00000100246
Uniprot IDs		Q7Z641 Q9UGU5	O96015
PDB IDs
Enriched GO Terms of Interacting Partners?		SUMO Transferase Activity Protein Sumoylation Protein Tag Activity Regulation Of RNA Splicing RNA Splicing MRNA Metabolic Process Nuclear Body Organization Nucleus Chromatin Remodeling Nucleic Acid Metabolic Process PML Body MRNA Processing Voltage-gated Calcium Channel Complex Nucleoplasm Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Binding Presynaptic Cytosol Postsynaptic Cytosol RNA Metabolic Process Slow-twitch Skeletal Muscle Fiber Contraction Skeletal Muscle Contraction SUMO Conjugating Enzyme Activity Positive Regulation Of Secretion Of Lysosomal Enzymes Uroporphyrinogen Decarboxylase Activity Carbohydrate Phosphatase Activity Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Chromatin Organization
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