CDH5 and SMG1

Number of citations of the paper that reports this interaction (PubMedID 10428027)
0

Data Source:
HPRD (in vivo)

		CDH5	SMG1
Description		cadherin 5	SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction External Side Of Plasma Membrane Cell Surface Membrane Catenin Complex Cell Junction Nuclear Membrane Anchoring Junction Cell Periphery	Nucleus Nucleoplasm Cytoplasm Cytosol Chromatoid Body
	Molecular Function	Signaling Receptor Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Signaling Receptor Complex Adaptor Activity Vascular Endothelial Growth Factor Receptor 2 Binding Transmembrane Transporter Binding Cadherin Binding Metal Ion Binding Fibrinogen Binding BMP Receptor Binding Cell-cell Adhesion Mediator Activity Protein Tyrosine Kinase Binding	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Telomeric DNA Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Cell Morphogenesis Endothelial Cell Morphogenesis Blood Vessel Maturation Cell Migration Involved In Sprouting Angiogenesis Intracellular Calcium Ion Homeostasis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Microtubule Polymerization Positive Regulation Of Protein-containing Complex Assembly Adherens Junction Organization Maintenance Of Blood-brain Barrier Regulation Of Vascular Permeability Blood Vessel Endothelial Cell Migration Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Bicellular Tight Junction Assembly Cell-cell Adhesion Protein Localization To Bicellular Tight Junction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay DNA Repair MRNA Export From Nucleus DNA Damage Response Peptidyl-serine Phosphorylation Regulation Of Telomere Maintenance Protein Autophosphorylation Phosphatidylinositol Phosphate Biosynthetic Process
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Lenalidomide FX06
Diseases
GWAS		Body size at age 10 ( 32376654) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High light scatter reticulocyte count ( 32888494) Iron status biomarkers (ferritin levels) ( 28334935) Lung function (FEV1/FVC) ( 30061609) Molar-incisor hypomineralization ( 23918034) Reticulocyte count ( 32888494)	Health literacy ( 31250787) Heel bone mineral density ( 30598549) Refractive error ( 32231278)
Interacting Genes		28 interacting genes: CA7 CDH1 CDH16 CDH3 CSK CTNNA1 CTNNB1 CTNND1 DSP EGFR EPHA2 F2RL2 FGA JUP KDR NQO1 P2RX4 P2RX6 PARD6A PKP4 PTPN11 PTPRB PYGB RND3 SHC1 SMG1 SRC VIM	11 interacting genes: CDH5 ELOB PRKCI RNF10 SMAD9 SMG5 SMG8 SNAPIN UPF1 UPF2 UPF3A
Entrez ID		1003	23049
HPRD ID		03075	06123
Ensembl ID		ENSG00000179776	ENSG00000157106
Uniprot IDs		P33151 Q59EA3	Q96Q15
PDB IDs			6L53 6L54 6SYT 6Z3R 7PW4 7PW5 7PW6 7PW7 7PW8 7PW9
Enriched GO Terms of Interacting Partners?		Cadherin Binding Cell Adhesion Anchoring Junction Cell Junction Catenin Complex Cell-cell Junction Organization Cell-cell Adhesion Cellular Response To Indole-3-methanol Response To Indole-3-methanol Regulation Of Protein Localization Adherens Junction Cell-cell Junction Plasma Membrane Cell Junction Organization Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of ERK1 And ERK2 Cascade Focal Adhesion Positive Regulation Of Protein Localization Adherens Junction Organization Cell Motility Cell-cell Junction Assembly Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cellular Localization Desmosome ERBB Signaling Pathway Cell Junction Assembly Regulation Of Cell Adhesion Regulation Of Transport Flotillin Complex Cell Adhesion Molecule Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of ERK1 And ERK2 Cascade Cell-cell Adhesion Mediated By Cadherin Response To Growth Factor Regulation Of MAPK Cascade Intercalated Disc Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Developmental Process Desmosome Organization Protein Tyrosine Kinase Activity Regulation Of Multicellular Organismal Process Shc-EGFR Complex Epithelial Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Protein Transport Cellular Response To Growth Factor Stimulus Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Catabolic Process Telomeric DNA Binding Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process Exon-exon Junction Complex Macromolecule Catabolic Process MRNA Transport RNA Transport Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Nucleobase-containing Compound Transport MRNA Export From Nucleus RNA Export From Nucleus Regulation Of Gene Expression MRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Catabolic Process Nuclear Export Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Regulation Of Glial Cell Proliferation Macromolecule Metabolic Process Positive Regulation Of RNA Splicing Nuclear Transport Nucleocytoplasmic Transport Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Late Endosome To Lysosome Transport Nucleic Acid Metabolic Process Cytosol Cytoplasm Negative Regulation Of Macromolecule Biosynthetic Process Response To Interleukin-1 Cytoplasmic Ribonucleoprotein Granule Negative Regulation Of Biosynthetic Process Cellular Localization Intracellular Monoatomic Ion Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Monoatomic Cation Homeostasis Regulation Of Gliogenesis Double-stranded DNA Helicase Activity Supraspliceosomal Complex VCB Complex Regulation Of Telomere Maintenance Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Golgi Vesicle Budding
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