CDH5 and CA7

		CDH5	CA7
Description		cadherin 5	carbonic anhydrase 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction External Side Of Plasma Membrane Cell Surface Membrane Catenin Complex Cell Junction Nuclear Membrane Anchoring Junction Cell Periphery	Cytoplasm Cytosol
	Molecular Function	Signaling Receptor Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Signaling Receptor Complex Adaptor Activity Vascular Endothelial Growth Factor Receptor 2 Binding Transmembrane Transporter Binding Cadherin Binding Metal Ion Binding Fibrinogen Binding BMP Receptor Binding Cell-cell Adhesion Mediator Activity Protein Tyrosine Kinase Binding	Carbonate Dehydratase Activity Zinc Ion Binding Lyase Activity Metal Ion Binding
	Biological Process	Cell Morphogenesis Endothelial Cell Morphogenesis Blood Vessel Maturation Cell Migration Involved In Sprouting Angiogenesis Intracellular Calcium Ion Homeostasis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Microtubule Polymerization Positive Regulation Of Protein-containing Complex Assembly Adherens Junction Organization Maintenance Of Blood-brain Barrier Regulation Of Vascular Permeability Blood Vessel Endothelial Cell Migration Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Bicellular Tight Junction Assembly Cell-cell Adhesion Protein Localization To Bicellular Tight Junction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process	Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Cellular PH Reduction Regulation Of Intracellular PH Neuron Cellular Homeostasis Regulation Of Chloride Transport
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Reversible hydration of carbon dioxide
Drugs		Lenalidomide FX06	Ethoxzolamide Benzthiazide Cyclothiazide Methazolamide Hydroflumethiazide Acetazolamide Zonisamide Diclofenamide Ellagic acid
Diseases
GWAS		Body size at age 10 ( 32376654) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High light scatter reticulocyte count ( 32888494) Iron status biomarkers (ferritin levels) ( 28334935) Lung function (FEV1/FVC) ( 30061609) Molar-incisor hypomineralization ( 23918034) Reticulocyte count ( 32888494)
Interacting Genes		28 interacting genes: CA7 CDH1 CDH16 CDH3 CSK CTNNA1 CTNNB1 CTNND1 DSP EGFR EPHA2 F2RL2 FGA JUP KDR NQO1 P2RX4 P2RX6 PARD6A PKP4 PTPN11 PTPRB PYGB RND3 SHC1 SMG1 SRC VIM	2 interacting genes: CDH5 FADS2
Entrez ID		1003	766
HPRD ID		03075	00263
Ensembl ID		ENSG00000179776	ENSG00000168748
Uniprot IDs		P33151 Q59EA3	P43166
PDB IDs			3MDZ 3ML5 6G4T 6H36 6H37 6H38 6SDT 6ZR9 7NC4 7P1A 8Q3U
Enriched GO Terms of Interacting Partners?		Cadherin Binding Cell Adhesion Anchoring Junction Cell Junction Catenin Complex Cell-cell Junction Organization Cell-cell Adhesion Cellular Response To Indole-3-methanol Response To Indole-3-methanol Regulation Of Protein Localization Adherens Junction Cell-cell Junction Plasma Membrane Cell Junction Organization Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of ERK1 And ERK2 Cascade Focal Adhesion Positive Regulation Of Protein Localization Adherens Junction Organization Cell Motility Cell-cell Junction Assembly Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cellular Localization Desmosome ERBB Signaling Pathway Cell Junction Assembly Regulation Of Cell Adhesion Regulation Of Transport Flotillin Complex Cell Adhesion Molecule Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of ERK1 And ERK2 Cascade Cell-cell Adhesion Mediated By Cadherin Response To Growth Factor Regulation Of MAPK Cascade Intercalated Disc Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Developmental Process Desmosome Organization Protein Tyrosine Kinase Activity Regulation Of Multicellular Organismal Process Shc-EGFR Complex Epithelial Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Protein Transport Cellular Response To Growth Factor Stimulus Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway	Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Blood Vessel Maturation Fibrinogen Binding Positive Regulation Of Cellular Response To Oxidative Stress Arachidonate Metabolite Production Involved In Inflammatory Response Positive Regulation Of Response To Oxidative Stress Acyl-CoA 6-desaturase Activity Acyl-CoA Desaturase Activity Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water Stearoyl-CoA 9-desaturase Activity Vascular Endothelial Growth Factor Receptor 2 Binding Endothelial Cell Morphogenesis Negative Regulation Of Microtubule Polymerization BMP Receptor Binding Production Of Molecular Mediator Involved In Inflammatory Response Alpha-linolenic Acid Metabolic Process Protein Localization To Cell-cell Junction Regulation Of Establishment Of Endothelial Barrier Regulation Of Cellular Response To Oxidative Stress Linoleic Acid Metabolic Process Regulation Of Establishment Of Cell Polarity Cell Migration Involved In Sprouting Angiogenesis Regulation Of Establishment Or Maintenance Of Cell Polarity Signaling Receptor Complex Adaptor Activity Regulation Of Endothelial Cell Differentiation Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Apoptotic Process Cell-cell Adhesion Mediator Activity Cell-cell Adhesion Mediated By Cadherin Catenin Complex Maintenance Of Blood-brain Barrier Epithelial Cell Morphogenesis Protein Tyrosine Kinase Binding Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of BMP Signaling Pathway Regulation Of Response To Oxidative Stress Long-chain Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Bicellular Tight Junction Assembly Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Vascular Permeability Tight Junction Assembly Adherens Junction Organization Fatty Acid Derivative Biosynthetic Process Tight Junction Organization Regulation Of Endothelial Cell Apoptotic Process Regulation Of Microtubule Polymerization Fatty Acid Derivative Metabolic Process Protein Localization To Cell Junction
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