WASHC1 and WASHC5

Number of citations of the paper that reports this interaction (PubMedID 20923837)
59

Data Source:
BioGRID (affinity chromatography technology, two hybrid, biochemical)

		WASHC1	WASHC5
Description		WASH complex subunit 1	WASH complex subunit 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Exocyst Cytoplasm Endosome Early Endosome Late Endosome Autophagosome Centriole Cytosol Cytoskeleton Membrane Cytoplasmic Vesicle Early Endosome Membrane Recycling Endosome Recycling Endosome Membrane WASH Complex	Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Cytosol Early Endosome Membrane Neuronal Cell Body WASH Complex
	Molecular Function	Actin Binding Protein Binding Ubiquitin Protein Ligase Binding Alpha-tubulin Binding Gamma-tubulin Binding Phosphatidylinositol 3-kinase Inhibitor Activity	Protein Binding
	Biological Process	Exocytosis Negative Regulation Of Autophagy Protein Transport Endosomal Transport Extracellular Matrix Disassembly Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Regulation Of Protein Ubiquitination Endocytic Recycling Arp2/3 Complex-mediated Actin Nucleation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Retrograde Transport, Endosome To Golgi	Oocyte Maturation Endosome Organization Lysosome Organization Positive Regulation Of Neuron Projection Development Protein Transport Endosomal Transport Actin Filament Polymerization Protein-containing Complex Localization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Polar Body Extrusion After Meiotic Divisions Protein-containing Complex Organization Regulation Of Actin Nucleation Meiotic Spindle Assembly Regulation Of Vesicle Size Endosome Fission
Pathways
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS
Interacting Genes		54 interacting genes: ABI2 ABI3 ATPAF2 BECN1 BLOC1S2 C14orf119 C1orf216 CDR2L CEP55 EIF3F EXOC8 FHL2 GYS1 HGS HSBP1 HSF2BP IFT57 KANK2 KLC3 KRT20 KRT26 KRT28 KRT3 KRT75 KRT76 LIMK1 LMO1 LMO2 LMO3 LMO4 MORN4 MRFAP1 NDC80 NUP62CL OIP5 OSTF1 POLR1C PRKAA2 RABGEF1 RNF2 SDCBP SMARCD1 TPM1 TPM3 TRIM69 TSG101 TTC19 TXLNA UBL5 USP20 WASHC3 WASHC4 WASHC5 ZBTB16	2 interacting genes: WASHC1 WASHC2C
Entrez ID		100287171	9897
HPRD ID			13786
Ensembl ID		ENSG00000181404	ENSG00000164961
Uniprot IDs		A8K0Z3	E7EQI7 Q12768
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Organelle Organization Cytoskeleton Organization Endosomal Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin-based Cell Projection Protein Binding Regulation Of Actin Nucleation Endosome Organization Organelle Localization Intermediate Filament Regulation Of Organelle Organization Positive Regulation Of Exosomal Secretion WASH Complex Transport Along Microtubule Regulation Of Actin Filament Organization Regulation Of Exosomal Secretion Cytoskeleton Cytoskeleton-dependent Intracellular Transport Early Endosome Membrane Cellular Localization Intracellular Transport Muscle Thin Filament Tropomyosin Microtubule-based Transport Cytosol Regulation Of Actin Cytoskeleton Organization Axo-dendritic Transport Regulation Of Extracellular Exosome Assembly Actin Filament Organization Establishment Of Organelle Localization Establishment Of Localization In Cell Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Protein Localization To Vacuole Late Endosome To Vacuole Transport Cytoskeleton-dependent Cytokinesis Regulation Of Cytoskeleton Organization Identical Protein Binding Cytoplasm Nuclear Speck Membrane Fission Exocytosis Vesicle Organization Regulation Of Stress Granule Assembly Cell Division	WASH Complex Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Nucleation Endocytic Recycling Retrograde Transport, Endosome To Golgi Cytosolic Transport Vesicle-mediated Transport To The Plasma Membrane Early Endosome Membrane Negative Regulation Of Barbed-end Actin Filament Capping Regulation Of Actin Filament Organization Endosomal Transport Early Endosome Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Barbed-end Actin Filament Capping Positive Regulation Of Cellular Component Biogenesis Regulation Of Cytoskeleton Organization Localization Within Membrane Phosphatidylinositol 3-kinase Inhibitor Activity Retromer Complex Binding Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly Protein Localization To Endosome Endosome Exocyst Positive Regulation Of Protein Depolymerization Arp2/3 Complex-mediated Actin Nucleation Phosphatidylinositol-5-phosphate Binding Actin Nucleation Phosphatidylinositol-3,5-bisphosphate Binding Phosphatidylinositol Phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding Protein Transport Gamma-tubulin Binding Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein-containing Complex Disassembly Vesicle-mediated Transport Phosphatidylinositol-3,4,5-trisphosphate Binding Regulation Of Organelle Organization Intracellular Transport Alpha-tubulin Binding Phosphatidylinositol-3-phosphate Binding Establishment Of Protein Localization Positive Regulation Of Actin Filament Polymerization Extracellular Matrix Disassembly Regulation Of Actin Filament Depolymerization Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Localization
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