WASHC5

Description		WASH complex subunit 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Cytosol Early Endosome Membrane Neuronal Cell Body WASH Complex
	Molecular Function	Protein Binding
	Biological Process	Oocyte Maturation Endosome Organization Lysosome Organization Positive Regulation Of Neuron Projection Development Protein Transport Endosomal Transport Actin Filament Polymerization Protein-containing Complex Localization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Polar Body Extrusion After Meiotic Divisions Protein-containing Complex Organization Regulation Of Actin Nucleation Meiotic Spindle Assembly Regulation Of Vesicle Size Endosome Fission
Pathways
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS
Novel Interacting Genes		2 novel interacting genes: WASHC1 WASHC2C
Interacting Genes		2 interacting genes: WASHC1 WASHC2C
Entrez ID		9897
HPRD ID		13786
Ensembl ID		ENSG00000164961
Uniprot IDs		E7EQI7 Q12768
PDB IDs
Enriched GO Terms of Interacting Partners?		WASH Complex Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Nucleation Endocytic Recycling Retrograde Transport, Endosome To Golgi Cytosolic Transport Vesicle-mediated Transport To The Plasma Membrane Early Endosome Membrane Negative Regulation Of Barbed-end Actin Filament Capping Regulation Of Actin Filament Organization Endosomal Transport Early Endosome Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Barbed-end Actin Filament Capping Positive Regulation Of Cellular Component Biogenesis Regulation Of Cytoskeleton Organization Localization Within Membrane Phosphatidylinositol 3-kinase Inhibitor Activity Retromer Complex Binding Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly Protein Localization To Endosome Endosome Exocyst Positive Regulation Of Protein Depolymerization Arp2/3 Complex-mediated Actin Nucleation Phosphatidylinositol-5-phosphate Binding Actin Nucleation Phosphatidylinositol-3,5-bisphosphate Binding Phosphatidylinositol Phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding Protein Transport Gamma-tubulin Binding Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein-containing Complex Disassembly Vesicle-mediated Transport Phosphatidylinositol-3,4,5-trisphosphate Binding Regulation Of Organelle Organization Intracellular Transport Alpha-tubulin Binding Phosphatidylinositol-3-phosphate Binding Establishment Of Protein Localization Positive Regulation Of Actin Filament Polymerization Extracellular Matrix Disassembly Regulation Of Actin Filament Depolymerization Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Localization
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