ZBTB33 and TRIM28

Number of citations of the paper that reports this interaction (PubMedID 36252888)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ZBTB33	TRIM28
Description		zinc finger and BTB domain containing 33	tripartite motif containing 28
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane	Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Protein-containing Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Krueppel-associated Box Domain Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-like Protein Ligase Activity Chromo Shadow Domain Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process Wnt Signaling Pathway Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Epithelial To Mesenchymal Transition DNA Repair Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Embryo Implantation Positive Regulation Of Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of Protein Import Into Nucleus Epigenetic Programming Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA Repair Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Convergent Extension Involved In Axis Elongation Embryonic Placenta Morphogenesis Genomic Imprinting
Pathways		Negative Regulation of CDH1 Gene Transcription	Generic Transcription Pathway SUMOylation of transcription cofactors HCMV Early Events Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins
Drugs
Diseases
GWAS			Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		11 interacting genes: CBFA2T3 CTNND1 GSDMD GYS1 NCOR1 NUDT22 PLS3 SELENOS SUMO2 SUMO3 TRIM28	90 interacting genes: CBX1 CBX3 CBX5 CCAR2 CDC34 CDC42 CDCA4 CDKN2A CEBPB CHAF1A CHD3 EAF1 ESR1 FBP1 FES H4C1 HDAC10 HTRA2 IRF1 IRF7 LIN28A LINC00624 LYN MAGEA2 MAGEA2B MAGEA6 MAGEC2 MAGED1 MAPKAPK2 MCM3 MCM5 MORC2 MYB NR3C1 NR4A1 NR4A3 NSMCE3 OGT PFDN5 PHF13 PPP2CA PRKAA1 PTEN RB1 RFC4 RNF4 SERTAD1 SERTAD2 SETDB1 SIN3A SIRT1 SKI SMARCAD1 SMURF2 SPG7 STAT3 SUMO2 TP73 TRIM24 TWIST1 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2L6 UBE2N UBE2U UBE3D URI1 VHL VIM YWHAQ ZBTB33 ZNF10 ZNF133 ZNF197 ZNF274 ZNF354A ZNF354C ZNF382 ZNF420 ZNF496 ZNF689 ZNF74 ZNF93
Entrez ID		10009	10155
HPRD ID		02269	03445
Ensembl ID		ENSG00000177485	ENSG00000130726
Uniprot IDs		Q86T24	Q13263
PDB IDs		2LT7 3FKC 3M4T 3M8V 4F6M 4F6N 5VMU 5VMV 5VMW 5VMX 5VMY 5VMZ 6DF5 6DF8 6DF9 6DFA 6DFB 6DFC 6V8U	1FP0 2RO1 2YVR 6H3A 6I9H 6QAJ 6QU1 7Z36
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Negative Regulation Of Glycolytic Process Regulation Of Generation Of Precursor Metabolites And Energy Protein Tag Activity SUMO Transferase Activity Negative Regulation Of D-glucose Transmembrane Transport Negative Regulation Of ATP Metabolic Process Ubiquitin-like Protein Ligase Binding Transcription Corepressor Activity Regulation Of Glycolytic Process Negative Regulation Of Blood Vessel Branching Structural Constituent Of Presynaptic Actin Cytoskeleton GDP-mannose Hydrolase Activity Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of D-glucose Transmembrane Transport Glycogen Synthase Activity, Transferring Glucose-1-phosphate Krueppel-associated Box Domain Binding Derlin-1-VIMP Complex UDP-sugar Diphosphatase Activity Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Ubiquitin-like Protein Ligase Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Negative Regulation Of Small Molecule Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Transmembrane Transport Positive Regulation Of Protein Localization To Cell-cell Junction Embryonic Placenta Morphogenesis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Localization To Cell-cell Junction Presynaptic Actin Cytoskeleton Organization Actin Filament Network Formation Convergent Extension Involved In Axis Elongation Chromo Shadow Domain Binding Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus	Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Ubiquitin Conjugating Enzyme Activity Nucleoplasm Cellular Response To Stress DNA Damage Response Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein-containing Complex PML Body DNA Binding Positive Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Protein Ubiquitination Macromolecule Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Response To Stress Modification-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Organization DNA-binding Transcription Factor Binding Protein Catabolic Process Chromatin Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein K48-linked Ubiquitination DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
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