CASP8AP2 and TCL1A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CASP8AP2	TCL1A
Description		caspase 8 associated protein 2	TCL1 family AKT coactivator A
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion PML Body	Nucleoplasm Endoplasmic Reticulum Cytosol Protein-containing Complex
	Molecular Function	Transcription Corepressor Activity Death Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Peptidase Activator Activity Involved In Apoptotic Process SUMO Polymer Binding	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Fas Signaling Pathway Negative Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway	Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Apoptotic Process Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		SUMOylation of transcription cofactors
Drugs
Diseases
GWAS		Asthma ( 31959851) Estimated glomerular filtration rate in non-diabetics ( 31451708) Major depressive disorder ( 29317602)	Adverse response to aromatase inhibitors ( 20876420) Mosaic loss of chromosome Y ( 27064253) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Plateletcrit ( 32888494) Refractive error ( 32231278)
Interacting Genes		19 interacting genes: CALM1 CASP10 CASP8 CREBBP CREM CTBP2 FADD FAS GLUL MX1 NAA10 NR3C2 PML SP100 SREBF2 TCL1A TRAF2 TRIM21 UBE2I	38 interacting genes: AKT1 AKT2 AKT3 ATM CADPS CALCOCO2 CARD9 CASP8AP2 CCDC13 CEP55 DDIT4L DNMT3A FLACC1 GOLGA2 H2AW INCA1 LNX1 LNX2 LSM3 NFKBIA NFKBID NIF3L1 NTAQ1 PPP1R13B PRTFDC1 REL TAX1BP1 TCF4 TEPSIN TNKS TP53BP2 TRAF1 TRAF2 TRMT61A TTC33 TXLNA TXLNB WDR47
Entrez ID		9994	8115
HPRD ID		06048	01744
Ensembl ID		ENSG00000118412	ENSG00000100721
Uniprot IDs		Q9UKL3	A0A024R6G5 P56279
PDB IDs		2LR8 6ANO 6AOZ 6AP0	1JSG
Enriched GO Terms of Interacting Partners?
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