KIAA0319 and SH2B1

Number of citations of the paper that reports this interaction (PubMedID 12421765)
41

Data Source:
HPRD (two hybrid)

		KIAA0319	SH2B1
Description		KIAA0319	SH2B adaptor protein 1
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GO Annotations	Cellular Component	Early Endosome Plasma Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Intracellular Membrane-bounded Organelle	Nucleus Cytosol Plasma Membrane
	Molecular Function	Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding
	Biological Process	Neuron Migration Response To Auditory Stimulus Negative Regulation Of Axon Extension Multicellular Organismal Response To Stress Negative Regulation Of Axon Extension Involved In Regeneration Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Dendrite Development	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Positive Regulation Of SMAD Protein Signal Transduction
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Radiation response ( 20923822) Serum uric acid levels ( 30993211) Waist-to-hip ratio adjusted for BMI ( 28552196)	Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 29381148 19079260 19079261 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Cognitive ability ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 28067908 21102463) Dental caries (decayed, missing and filled teeth) ( 31533690) Educational attainment ( 25201988) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Lamb consumption ( 32066663) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Obesity ( 23563607) QT interval ( 29213071) Red blood cell count ( 32888494 27863252) Waist circumference ( 25673412) Weight ( 19079260)
Interacting Genes		3 interacting genes: APP FEM1B SH2B1	17 interacting genes: CSAD EGFR ERBB2 ERBB3 ERBB4 FGFR3 FRS3 GRB2 IGF1R INSR JAK2 KIAA0319 MET NTRK1 NTRK2 RHBG SH2B2
Entrez ID		9856	25970
HPRD ID		18713	12336
Ensembl ID		ENSG00000137261	ENSG00000178188
Uniprot IDs		A0A087X0U9 Q5VV43	A0A024QZ92 A0A024QZC2 A0A024QZD2 B3KNV5 B4DLN5 Q9NRF2
PDB IDs		2E7M	5W3R
Enriched GO Terms of Interacting Partners?
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