SH2B1 and RHBG

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		SH2B1	RHBG
Description		SH2B adaptor protein 1	Rh family B glycoprotein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Cytoplasmic Vesicle Membrane Anchored Component Of Plasma Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding	Ammonium Transmembrane Transporter Activity Ankyrin Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Positive Regulation Of SMAD Protein Signal Transduction	Ammonium Transport Transepithelial Ammonium Transport Ammonium Transmembrane Transport
Pathways		Factors involved in megakaryocyte development and platelet production	Rhesus glycoproteins mediate ammonium transport.
Drugs
Diseases
GWAS		Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 29381148 19079260 19079261 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Cognitive ability ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 28067908 21102463) Dental caries (decayed, missing and filled teeth) ( 31533690) Educational attainment ( 25201988) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Lamb consumption ( 32066663) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Obesity ( 23563607) QT interval ( 29213071) Red blood cell count ( 32888494 27863252) Waist circumference ( 25673412) Weight ( 19079260)	Initial pursuit acceleration ( 29064472) Subcutaneous adipose tissue ( 22589738) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		17 interacting genes: CSAD EGFR ERBB2 ERBB3 ERBB4 FGFR3 FRS3 GRB2 IGF1R INSR JAK2 KIAA0319 MET NTRK1 NTRK2 RHBG SH2B2	4 interacting genes: CYSRT1 KRTAP19-1 KRTAP19-2 SH2B1
Entrez ID		25970	57127
HPRD ID		12336	06152
Ensembl ID		ENSG00000178188	ENSG00000132677
Uniprot IDs		A0A024QZ92 A0A024QZC2 A0A024QZD2 B3KNV5 B4DLN5 Q9NRF2	Q9H310
PDB IDs		5W3R
Enriched GO Terms of Interacting Partners?
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